Sensitivity gains for the evolution of routine bioanalysis
The rapid advancement of the drug pipeline demands sensitivity to allow a more complete pharmacokinetic characterization of low-dose drug candidates at low detection limits. The SCIEX 7500 system will enable pharmaceutical researchers to continue to explore lower dosage, higher efficacy compounds and to improve the efficiency of routine bioanalysis. Learn more in this technical note.
Pharmacologically relevant measurement of high potency drug candidates with improved sensitivity in In-vitro transporter assays
In drug discovery, being able to perform pharmacologically relevant measurements of drug candidates and evaluate the transporter at early-stage development is crucial when selecting drug safety profiles. The SCIEX 7500 system offers you enhanced sensitivity to reduce compound concentrations, so it’s more biologically relevant. Download this technical note to see how you can get higher-quality data.
High sensitivity MRM workflow for signature peptide quantification workflow
Quantification of peptide/protein therapeutics in biological matrices is crucial for therapeutic development. Download this technical note, which demonstrates a robust method that uses the SCIEX 7500 system to quantify a series of surrogate peptides in rat plasma at ultra-low LLOQs, ranging from 5 to 39 fmol/mL.
Improved LC-MRM quantification sensitivity for cyclic peptides from the natriuetic peptide family
Quantifying trace-level cyclic peptides in biological matrices is extremely challenging. The SCIEX 7500 system can offer outstanding reproducibility, precision, accuracy and linearity to ease these challenges. Download this ultra-sensitive, MRM-based cyclic peptide quantification workflow.
Achieve broad lipid quantitation using a high-throughput targeted lipidomics method
The complexity of the lipidome is very high, with a huge diversity in lipid molecular species, making comprehensive quantitative profiling challenging. Download this technical note to find out about a targeted MRM assay approach that enables quantification of a broad array of different lipids at the molecular species level using the SCIEX 7500 system.
Reproducible targeted peptide profiling using highly multiplexed MRM assays
Quantitative robustness key to ensuring both large and small biological changes are accurately measured across large sample cohorts. The SCIEX 7500 system offers you high sensitivity as well as a wide linear dynamic range for large-scale, targeted peptide quantification. Download this technical note to learn more.
Highly sensitive pesticide analysis in baby food
Detecting and quantifying pesticide residues in food remains a moving target as food regulations drive the pursuit of lower limits of quantification. This technical note demonstrates the high sensitivity of the SCIEX 7500 system in quantifying 209 pesticides, easily achieving sub-ppb detection limits with a very small injection volume.
Precise testing of pesticides in food using the SCIEX 7500 system
The global scale of pesticide use and its impact on food safety and authenticity regulations have led to the need for sensitivity analysis that can achieve trace levels. Download this technical note to learn more about how the SCIEX 7500 system offers sensitivity, robustness and accuracy with 700 compounds achieving limits as low as 0.2 ng/mL.
The Direct aqueous analysis of pesticides and PPCPs in drinking and bottled water at parts per trillion levels
Water can be a challenging matrix, especially if it is sourced from a
river, lake or reservoir before entering the water treatment process. Laboratories that perform testing for water companies must
have highly sensitive instrumentation to handle these matrix challenges and meet regulatory requirements. This technical note demonstrates the sensitivity levels of the SCIEX 7500 system during water testing.
High-sensitivity detection of forensic drug panel in human whole blood
In a forensic laboratory, the ability to accurately quantify large panels of analytes in complex biological matrices over a wide range of concentrations is challenging, and it often requires dilution of the samples to bring them within the calibration range of the instrument. In this technical note, the SCIEX 7500 system demonstrates exceptional performance in speed, linear dynamic range and sensitivity to overcome this challenge, quantifying a panel of 49 drugs in human whole blood.
Ultra-sensitive analytical methodology for the quantification of 11-nor-9-carboxy-THC (THC-COOH) in oral fluid
The detection and quantification of THC in drug screening can result in a high number of false positives since this analyte can be found in subjects passively exposed to cannabis. The SCIEX 7500 system offers you high sensitivity, robustness and performance to accurately quantify pg/mL levels of THC-COOH in oral fluid, without the need for derivatization.