Generation Quant

Episode 3 : Explosion

By enabling atmospheric pressure ionization, the discovery of collision focusing created a “big bang” in the field of mass spectrometry. This led to a decade of speed and sensitivity improvements that revolutionized the quantitative analysis industry.

05 / 17 / 2019 | Author: SCIEX

“We were suddenly presented with this new combination of software and hardware that exhibited incredible speed—that’s why people adopted it,” says Liz Thomas, cofounder and former CEO of Alderley Analytical. Exponential increases in sensitivity over the decade that followed the discovery of collision focusing earned SCIEX the reputation of the gold standard in quantification. Pushing the limits of quantification lower and lower, and turning hours of LC analyses into minutes, shifted an entire industry to LC-MS/MS technology.

“These [solutions] solved problems that had existed for decades, and that was how to measure analytes in an LC flow reproducibly, and with high sensitivities and signal-to-noise ratios that were just not possible before.”

Jim Hager