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Researchers performing drug metabolism studies on large complex molecules face a challenging task. These biotherapeutics can be very diverse and unpredictable, with countless possibilities as to how a molecule breaks down or becomes altered when it is in vivo. This makes detection, identification and interpretation of catabolites and biotransformations extremely complex and time consuming, with significant consequences if anything is missed.
SCIEX has developed cutting-edge LC-MS solutions for scientists that need to quickly and accurately analyze catabolism and biotransformation of large molecule biotherapeutics, including peptides, proteins, antibodies and antibody drug conjugates (ADCs), even those with custom modifications, cyclizations, disulfide bonds and engineered amino acids.
Never again will you need to manually process and interpret data, or muddle through reports from multiple software packages. With efficiency in mind, you can now fully automate your workflows and experience the genuine ease and sophistication of high-resolution MS/MS data from a single platform.
Our innovate LC-MS solutions are designed specifically to cut through the complexities of large molecule biotherapeutics, moving you closer to analytical precision while boosting the productivity and reliability of your development pipeline. Now you can accurately and effortlessly interpret peptides and proteins, and overcome the challenges of analyzing ADCs.
Whether you need to quickly analyze the structure for the top catabolites in a sample, or you are doing comprehensive biotherapeutic catabolism and biotransformation studies, you need the best solution for acquiring data. Now you can get the answers you need with high-resolution accurate mass QTOF systems and MetabolitePilot 2.0 software from SCIEX.
For research use only. Not for use in diagnostic procedures.
The complexity of large molecule breakdown makes catabolite identification a very difficult manual task. Now you can employ the same automated processing and assignment for large molecule catabolites as for drug metabolites. MetabolitePilot Software 2.0 enables automated catabolite identification using sophisticated processing algorithms. Fast, automated and comprehensive peptide catabolism and biotransformation identification allow you to find liabilities and soft spots in the molecule. The Correlation workspace offers three levels of review to maximize your confidence and minimize the time required for data analysis.
MetabolitePilot Software 2.0 has processing logic specific for large molecule catabolism, including peptides, proteins and fusion proteins. The software can support the analysis of linear, non-linear, cross-linked and cyclic peptides, as well as inclusion of engineered amino acids and modifications, providing you with a prediction of catabolites and hydrolytic cleavages for use in targeted searching. There isn’t any need for complex and laborious input of structures or bonds, simply define your molecules using the 1-letter amino acid codes, or import of a .mol file.
Studying metabolism of antibody drug conjugates (ADCs) is especially complex, because you need to monitor the breakdown or release of the cytotoxic drug, as well as the ADC linker and antibody. Harness the built-in intelligence of MetabolitePilot Software 2.0 to set up your ADC metabolism analyses quickly, with dedicated templates in the Processing view. You have the Flexibility to define antibody, linker, conjugation chemistry and cytotoxic drugs with the intuitive user interface.
If you need to quickly detect, identify and determine the structure for the top catabolites in a sample, the Routine Biotransform Solution is the right choice. Combining the revolutionary X500 QTOF System, SCIEX OS and MetabolitePilot Software 2.0, you can get fast and efficient answers on your biotherapeutic catabolism faster than you ever thought possible.
For high accuracy, reliability and repeatability across thousands of injections, with maximum uptime
Compact, accurate and robust with the renowned, robust Turbo V™ ionization source, so you can focus on running samples
Intuitive point-and-click acquisition software makes it easier than ever to set-up and run your methods
If you are doing in-depth, comprehensive biotherapeutic catabolism and biotransformation studies, the Advanced Biotransform Solution is ideal for you. The high-resolution accurate mass TripleTOF 6600 QTOF System is paired with SWATH Acquisition and MetabolitePilot Software 2.0 to deliver the linear dynamic range and sensitivity to analyze low-level metabolites and catabolites in complex matrices.
Delivers high-accuracy, reliability and repeatability across thousands of injections, with maximum uptime
The highest confidence for drug metabolism and catabolism studies with high sensitivity and wide linear dynamic range of >5-orders
Proprietary variable window SWATH® Acquisition provides high-speed, high-resolution MS/MS data of all detectable metabolites in a sample with a single injection
Biotransform Overview Solution Guide
Advanced Biotransform Solution Guide
Routine Biotransform Solution Guide
Webinar: Confident and Powerful MetID for All Your Therapeutic Molecules
Technical Note: Metabolite Identification of Payload Species of ADCs with Noncleavable Linkers
Technical Note: Therapeutic Peptide Catabolite Identification
Product Bulletin: MetabolitePilot™ Software 2.0
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