Intact protein analysis

Select lead candidates with confidence and ensure reproducible product quality. Discover fast and reliable protein analysis solutions that simplify identification and characterization of complex molecules at the intact level.

Introducing the Intabio ZT system coupled with the ZenoTOF 7600 system

Accurate PTM identification at the intact protein level

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Overview

Reclaim your time for innovation with solutions for intact protein analysis that inform decision-making and reduce risk throughout the development pipeline.

One of the challenges with intact protein analysis is the lack of a high-resolution separation approaches that couple to mass spectrometry. As a result, mass spectrometry adoption tends to occur more in the later stages of early development, after candidates have been narrowed down by other methodologies. This approach provides less qualitative information, however.

When bringing new modalities to market, including new and complex next-generation therapies, there is a need to gain critical information and greater insight during early development in order to reduce risk downstream.

Solutions for comprehensive intact biotherapeutic analysis enable confident selection of lead candidates during early-stage development and continued monitoring of product quality attributes through to commercialization.

Rapid comprehensive intact protein analysis

Workflow

Acquire multiple pieces of critical data from your intact protein analysis workflow.

Leverage the high-resolution separation capabilities of imaged capillary isoelectric focusing (icIEF) and gain greater perspective by collecting heterogeneity information on multiple samples.

The combination of icIEF separation, with UV quantitation and mass spec identification provides high-resolution separation and comprehensive characterization of intact monoclonal antibodies (mAbs) and their charge variants in a single assay, on a single platform. Obtain this critical information earlier in the development process and inform better decision making.

  • Rapid screening without time-consuming manual operations
  • Intuitive data visualization for more confident screening and selection
  • Achieve consistent annotation of intact LC-MS data

High-throughput intact protein analysis

Workflow

Confirm drug identity, monitor product quality and perform comparative studies with a high-throughtput LC-MS workflow.

  • Rapid screening without time-consuming manual operations
  • Intuitive data visualization for more confident screening and selection
  • Achieve consistent annotation of intact LC-MS data

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Associated applications

Charge heterogeneity analysis

Pursue the end goal with confidence. Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.

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Multi-attribute methodology

Pursue simpler, faster and more accurate product quality profiles. Reclaim time for innovation and reduce overall analytical testing burden with software solutions for product quality attribute (PQA) monitoring.

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