Quadrupole Time-of-Flight for Biologics

Standardized Biologics Characterization Workflows Have Never Been Easier

Built specifically for biologics characterization, the X500B QTOF System will help you boost your analytical capacity, simplify workflows and accelerate throughput in a matter of days. This high resolution Quadrupole Time-of-Flight (QTOF) system combines robust and reliable instrumentation with powerful and intuitive software to get you to characterization answers faster and easier, in a true benchtop platform. And with tools to enable a complete Multiple Attribute Methodology (MAM) Workflow, to allow you to define, track and quantify product quality attributes as well as specified contaminants, or find new unspecified impurities in a single software solution.

X500B: A Quadrupole Time-of-Flight Mass Spec for Biologics
Key Features

Novel N-optic TOF design gives optimal mass accuracy and resolution, even for large biotherapeutics such as mAbs and antibody drug conjugates

Renowned Turbo V™ source provides efficient ion production while limiting contamination for maximized robustness and uptime

Purpose built for biologics characterization and engineered with ease-of-use and simplicity in mind to accelerate and streamline biotherapeutic analysis

Perform intact mass, subunit analysis, and peptide mapping characterization on this single, true benchtop system

Clear Confident Answers with Automated Data Processing

The powerful data processing and high impact visualization in BioPharmaView™ Software empowers analytical scientists, enabling them to process data into high quality answers on their biotherapeutics.

Simple and Automated

Rapidly turn your biologics characterization data into answers with the BioPharmaView™ Software.

Powerful and Precise

Explore the new features of the BioPharmaView Software, including disulfide bond localization and automated DAR calculations.

Complete Workflow for MAM

Develop and implement a multiple attribute methodology (MAM) workflow with the new capabilities of BioPharmaView™ Software 3.0 to accelerate your biologic development.

Simple and Streamlined from Start to Finish

min

Easy to Learn, Compact and Robust

Size

A compact true benchtop system, with an ambidextrous dress panel to easily fit in your available space

Calibration

Automated on-board calibration and dual-spray source gives worry free acquisition

Ionization Source

Renowned, SCIEX Turbo V™ Ionization Source for maximum robustness

Maintenance

Easy Qjet™ Ion Guide access for straightforward maintenance

Operating System

The all-new SCIEX OS user interface is incredibly easy to learn and maintain

Mass Accuracy

Heated TOF path eliminates environmental temperature impact

Data Processing Software

BioPharmaView™ Software delivers data visualization and automated calculations for intact, subunit, and peptide level analyses

Purpose-Built for Biologics Characterization

The First High Resolution QTOF Specifically for Biologics

The X500B QTOF System was designed from the ground up to accelerate every day biologics characterization workflows.

Intact Mass Analysis

Answers, Simple and Streamlined Solutions for biotherapeutic intact mass analysis that gives you better information for better biologics decisions

Peptide Mapping

Simple Solutions to Complex Workflows Comprehensive biotherapeutic peptide mapping workflows for better information, faster

Antibody-Drug Conjugates (ADC)

DAR, Demystified
Learn how to focus on moving your antibody drug conjugate (ADC) through development

Lot Comparability

Compare It and Share It Easily identify differences from lot-to-lot, even with large data sets

Multiple Attribute Methodology (MAM)

Implement a complete solution for MAM to streamline biotherapeutic analysis and purity testing throughout development

See how easy the Intact Mass Analysis workflow is with this Interactive Demo

Hear from the Experts & See the X500B System in Action

More Than Just a Mass Spec

The X500B QTOF is a Complete Solution for Biologics Characterization. The X500B provides a complete solution, designed to elevate your biologics characterization to a whole new level of productivity.

ExionLC™ System

A perfect match for the X500B QTOF system, delivering reliability and repeatability.

SCIEX OS

Our newest operating platform, built for remarkable simplicity and productivity.

BioPharmaView Software

Fast biologics characterization and data visualization, including automated DAR and PTM ratio calculations.

Learning Center

Standard Biologics Characterization Executive Brief
Intact Mass Analysis Solution Guide
Peptide Mapping Solution Guide
Biotherapeutic Comparability Solution Guide
X500B Method Flyers
Intact Analysis of Antibody Drug Conjugates
Glycosylated and Deglycosylated Subunit Analysis of Antibody Drug Conjugates
Comparative Peptide Mapping Between Two Manufacturers of Trastuzumab Using the X500B QTOF System
Routine Workflow for Comparability Assessment of Protein Biopharmaceuticals
Comparative Multi-Supplier Lot Analysis of Trastuzumab Using Subunit Analysis on the X500B QTOF System
SCIEX OS Introduction Videos
MAM Workflow Executive Brief
MAM Overview Brochure
BPV 3.0 Software Bulletin