Supplements and natural health products analysis

Unlock nature's secrets with precision. Elevate your supplements and natural health products analysis with mass spectrometry.

Health supplements drive demand for enhanced testing against fraud and to ensure integrity

Global demand for supplements testing is rising sharply as an increasing number of supplements are being sold online. Increased health consciousness in developed countries is a main driver for this demand. In regions of the world where health care is expensive or unreliable, people also turn towards natural remedies and nutritional supplements.

However, not all supplements are safe.

Processed herbal products like tea mixtures or capsules with herbal powders pose a risk for adulteration, containing undeclared ingredients which have been added either intentionally or unintentionally.

Intentionally Added Substances:

Compounds such as pharmaceuticals and other chemicals have been identified in natural health products.

    • Weight loss products have been found contain undeclared active pharmaceuticals.
    • Antioxidant products like turmeric have been found to contain carcinogenic dyes.

    Unintentionally Added Compounds:

    Environmental conditions can influence metabolites in plants and therefore affect the final formulation.

    The replacement of one plant commodity with another one or unintentional co-harvest of toxic-containing weeds are issues that require attention in supply chains.

      • By-harvested plants that contain liver-toxic alkaloids have been found in children's tea.
      • Trending mushroom formulations like gummies or drink powders pose a risk of containing mushroom species with illegal active substances such as psilocybin.

      To maintain effectiveness and quality, it is important for manufacturers to characterize raw materials.

      Food supplements and additives were the second most seized food type, by quantity, after alcoholic beverages in Interpol’s annual food fraud operation, Operation Opson X in 2021.

      SCIEX provides solutions to addressing both intentional and unintentional adulteration.

        • Targeted ingredient analysis
        • Adulteration testing which can be targeted compound analysis or non-targeted screening

        SCIEX OS software is intuitive to allow first-users to navigate information-rich data sets such as non-targeted screening data. Statistical analysis becomes smarter and faster with data visualization tools. Compound libraries enable customers to identify unknown natural product compounds. Along with the HR-MS information, which is available in the Natural Products Library - Traditional Chinese Medicine, this library product contains additional compound entries with structural information and MS/MS spectra.

          Monitoring the effects of agricultural practices on highly traded commodities

          Setting a new standard for compound discovery in citrus fruits with metabolomics

          Commercial citrus fruits undergo continuous agricultural practices to improve their flavor, appearance and nutritional value, for example. As these attributes are closely associated with the citrus metabolite composition, metabolomics can be used to monitor changes in metabolite profiles from preharvest practices that are targeted toward optimizing fruit quality.

            • Confidence in identifying low-level or even previously undetected compounds
            • Signal-to-noise enhancements increase the quality of chromatographic peaks extracted from fragment masses in Zeno MRMHR
            • A single LC-MS/MS method for structurally diverse components —such as sugars, organic acids, amino acids, flavonoids, limonoids and lipids

            Supplements and natural products workflow

            Solution

            SCIEX high resolution mass spectrometry solution for product characterization.

            • Characterization of raw materials
            • Unknown screening of raw and finished products
            X500R QTOF system

            A uniquely engineered and versatile QTOF build to handle the demands of any high throughput laboratory.

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            SCIEX OS software

            Unleash the analytical power of the next-generation software platform for data acquisition and processing.

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            MarkerView software

            Designed with non-statisticians in mind and intuitively developed, MarkerView software does the heavy lifting so you can focus on high-value decisions like reviewing trends and differences in targeted or untargeted mass spec workflows. Distill complex datasets quickly, find statistically significant differences and reveal key insights faster. MarkerView software is now integrated into the SCIEX OS ecosystem.

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            Natural Products High Resolution MS/MS Spectral Library

            The Natural Products HR-MS/MS Library contains the high resolution MS/MS spectra in positive and negative ion mode (where appropriate) comprising more than 2,500 compounds assoicated with natural products and traditional medicines.

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