Lipidomics research enhances our understanding of lipid biology and its implications for human health, disease and environmental interactions. By elucidating the intricate role of lipids within biological systems, lipidomics contributes to the development of innovative diagnostic tools, therapeutic approaches and preventative strategies, all geared towards enhancing public health and overall well-being.
Lipidomics
Empowering lipidomics researchers to unlock the intricate world of lipids.
Untangling the intricacies of the lipidome
Overcoming the challenges of lipid analysis
There are persistent hurdles to cross when identifying and quantifying diverse lipid classes and species in complex biological samples, and overcoming these obstacles is crucial.
SCIEX LC-MS/MS solutions empower researchers to delve into the lipidome to meticulously characterize subtle distinctions between lipid species and screen similar compounds with enhanced clarity and confidence. Our mass spectrometry portfolio provides powerful tools that deliver precise and comprehensive insights into the intricate realm of lipids. Uncover their complexities with confidence through our advanced technology.
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Targeted identification and quantitation
Comprehensive lipid profiling analysis
SCIEX solutions for targeted lipidomics are built using proven technology that delivers highly accurate, selective, sensitive and reproducible quantitation.
The SCIEX Triple Quad 6500+ system and the SCIEX 7500 system target thousands of lipids in a single experiment, rapidly switching between positive-ion and negative-ion mode to quantify potential biomarkers and elucidate metabolism at the lipid level.
Equipped with electron activated dissociation (EAD) technology, the ZenoTOF 7600 system enables full characterization of lipid species, all within a single experiment, and supports:
- The speed, sensitivity and dynamic range required for large-scale quantitative lipid profiling
- The characterization and structural elucidation of lipid species using EAD
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Targeted profiling of lipid mediators
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Achieve broad lipid quantitation using a high-throughput targeted lipidomics method
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Characterization of liposomes as a drug delivery vehicle
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Cutting into tallow: A lipidomic exploration of animal-based and alternatively sourced meat
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Quantitative and qualitative analysis of steroids by high-resolution mass spectrometry
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Untargeted lipidomics
Understanding lipid biology with discovery and translational lipidomics
SCIEX solutions for untargeted lipidomics have the power to fully characterize subtle differences between lipid species and screen more compounds with better clarity. The unique electron activated dissociation (EAD) fragmentation technology available on the ZenoTOF 7600 system enables the complete characterization of a lipid species, within a single MS/MS experiment, and supports:
- Comprehensive and reproducible mapping of lipid species for the discovery of even low-level differentially regulated lipids
- Precise and unambiguous structural elucidation of lipids using EAD
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Improve selectivity with differential ion mobility
Accurate lipid quantitation requires distinguishing the target lipid species from isomers, interferences and background. The SelexION device adds an orthogonal strategy for separation of isobaric and isomeric species and supports:
- Gas phase separation of the lipid classes prior to the MS/MS analysis
- Easy installation by the user in minutes
- Coupling with flow injection analysis (FIA) or chromatographic workflows (HPLC, UHPLC)
- Optional chemical modifiers to further increase the separation power, enabling the targeting of even the most difficult-to-resolve lipid isomers
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Differential mobility separation for improving lipidomic analysis by mass spectrometry
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Differential ion mobility separation of glycosylceramides (cerebrosides)
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Differential ion mobility separation of iso-elemental lipid species
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Resolution of ether- and diacyl-linked phospholipids by differential ion mobility spectrometry (DMS)
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Resolution of sphingomyelins in complex lipid extracts by differential ion mobility spectrometry (DMS)
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Sensitive and accurate quantitation of retinoic acid isomers in biological samples
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Differential mobility spectrometry resolves chlorine- and acetate-adducts of phosphatidylcholine (PC)
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Separation of bile acid isomers with differential mobility spectrometry
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Quantification of lipids by flow injection analysis and differential mobility spectrometry
Workflow related components
Accurate MS with the ZenoTOF 7600 system
Get qualitative flexibility combined with quantitative power. The ZenoTOF 7600 system represents a crucial step change in MS/MS technology with electron activated dissociation and provides a new level of power for characterizing the lipidome.
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Targeted lipidomics with the SCIEX 7500 system
Quantify lipids with the SCIEX 7500 system, which offers high sensitivity and a wide linear dynamic range that is ideal for large-scale targeted quantitation.
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Orthogonal lipid separation with the SelexION device
A new dimension in selectivity through lipid class separation provides more confident identification and better quantitation. Differential ion mobility also enables isoelemental and isobaric separation within lipid classes to help improve quantitation results.
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High-throughput mass spectrometry with the QTRAP 6500+ system
Discover a detection and quantitation workhorse with a wide range of workflows for lipid analysis. Answer the toughest biological questions with quantitative MRM and MRM3, qualitative QTRAP system scans, the SelexION device and the ability to mix and match in a single run.
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ExionLC AE system
Discover reproducibility, reliability and carryover performance to match your quantitative workflows. Experience dependability you can count on from injection to injection and batch after batch.
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SCIEX OS software
Unleash the analytical power of a next-generation software platform for data acquisition and processing.
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Service
Keep your instruments performing at their peak with multiple options for response time, repair coverage and maintenance.
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Thought leaders
Extraordinary science
Step into the captivating realm of groundbreaking science with biomedical and omics researchers using the ZenoTOF 7600 system.
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Dr. Martin Giera
Associate Professor, Head Metabolomics Group, Leiden University Medical Center (LUMC)
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SCIEX Omics community
Chat with your peers about how to get the most out of your proteomics, metabolomics and lipidomics studies.
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