Echo® MS system

run fast

This Acoustic Ejection Mass Spectrometry (AEMS) system delivers speed, scale and unyielding data quality to high-throughput screening laboratories working with complex biology. Combining industry leading quantitative MS-based detection from SCIEX with ultra-fast, contactless sampling capabilities, the Echo MS system can help redefine your current and future high-throughput workflows.

Echo MS system

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Redefining high-throughput quantification workflows.

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Speed

Speed

Conquer throughput barriers with sampling speeds of up to 3 samples per second with AEMS technology. Screen substrate and product simultaneously with the Echo MS system that allows you to RUN FAST and enter a new era in high-throughput quantitative analysis.

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Scale

Scale

Compatible with 384 and 1536-well plates as well as any robotic system for automation, the “sans-LC” Echo MS system breaks through the bottlenecks of conventional LC-MS/MS workflows. Use less sample, and transform your project timelines. Go from weeks to a matter of days, all while retaining the precise, information-rich answers that let you make decisions about your lead compounds faster.

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Precision

Precision

Unparalleled standards of quantification. The Echo MS system provides consistent and precise reproducibility in challenging matrices. Its high specificity enables confidence in results and limits the needs for re-runs, all while saving on reagent costs compared to other technologies.

Having data same day is a very big step. In terms of what the decision makers are getting, they are literally shipping the compounds and potentially getting results the same day.
Simon WoodHead of Analytical Science, Cyprotex. Macclesfield, UK

Explore the Echo MS system.

Echo MS module

A pioneering combination of Acoustic Droplet Ejection (ADE) and the Open Port Interface (OPI) enables ultra-fast, contactless sampling, and worry-free, efficient integration into full automation solutions.

SCIEX Triple Quad 6500+ mass spectrometer

With its high sensitivity and wide linear dynamic range, the industry-proven SCIEX 6500+ system can deliver accurate quantification of both small and large molecule classes in diverse, complex matrices.

7500 system 7500 system
Acoustic Droplet Ejection (ADE)
Acoustic Droplet Ejection (ADE)

Acoustic Droplet Ejection (ADE)

ADE technology delivers nanoliter droplets in a contactless manner with high speed, precision and accuracy.

Open Port Interface
Open Port Interface

Open Port Interface

The OPI is a continuous-flow, self-cleaning, simple and versatile sampling interface for liquid introduction to atmospheric pressure ionization mass spectrometry. Directly eject complex samples with no sample loss or carry over, and overcome the typical challenges of liquid chromatography.

Echo MS probe
Echo MS probe

Echo MS probe

Intelligent probe sensing technology automatically adjusts the settings for the system source to an optimal range for best spray conditions, eliminating manual adjustments on the source and decreasing optimization time.

SCIEX OS software
SCIEX OS software

SCIEX OS software

With enhanced data acquisition and automated processing productivity, the compliance-ready software enables seamless implementation and operation of the Echo MS system in your high-throughput laboratory set-up.

OptiFlow Turbo V ion source
OptiFlow Turbo V ion source

OptiFlow Turbo V ion source

The zero-touch optimized source requires no manual adjustment to optimize the spray.

Acoustic Droplet Ejection (ADE)

ADE technology delivers nanoliter droplets in a contactless manner with high speed, precision and accuracy.

Open Port Interface

The OPI is a continuous-flow, self-cleaning, simple and versatile sampling interface for liquid introduction to atmospheric pressure ionization mass spectrometry. Directly eject complex samples with no sample loss or carry over, and overcome the typical challenges of liquid chromatography.

Echo MS probe

Intelligent probe sensing technology automatically adjusts the settings for the system source to an optimal range for best spray conditions, eliminating manual adjustments on the source and decreasing optimization time.

SCIEX OS software

With enhanced data acquisition and automated processing productivity, the compliance-ready software enables seamless implementation and operation of the Echo MS system in your high-throughput laboratory set-up.

OptiFlow Turbo V ion source

The zero-touch optimized source requires no manual adjustment to optimize the spray.

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What the experts say...

Resource Library

  • Technology Technology
  • Technical Notes Technical Notes

Rapid MS/MS analysis with acoustic ejection mass spectrommetry (AEMS)

SCIEX Echo MS system breaks bottlenecks in quantitative mass spectrometry throughput. Here a newly developed Acoustic Ejection Mass Spectrometry (AEMS) platform - the SCIEX Echo MS system - is described for rapid, chromatography-free MS/MS analysis. It showcases the potential to dramatically change the field of high-throughput analysis.

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  • Pharma Pharma
  • Technical Notes Technical Notes
  • New

Accelerated pharmacokinetic profiling and metabolite monitoring using Echo MS system

Here, the viability of the use of the Echo MS system for candidate screening is explored. The data confirm the utility of this high-throughput solution for early discovery phase studies with its ability to overcome the analytical bottlenecks of traditional LC-MS solutions through speed and quantitative performance.

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  • Pharma Synthetic biology
  • Technical Notes Technical Notes
  • New

High-throughput metabolite quantification for synthetic biology

Here, a quantitative approach for the rapid screening of 90 yeast strains using the Echo MS System was demonstrated, monitoring over 60 metabolites. The goal of publishing this workflow is to demonstrate the ability of the Echo MS System to rapidly screen a biological matrix for key metabolites of interest with significantly reduced analysis times..

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  • synthetic Pharma
  • Technical Notes Technical Notes

True high-throughput bioanalysis using the Echo MS system

Echo MS system offers throughput benefits for early stage bioanalytical studies. Minimal and no sample preparation are compared, with the results showing sample prep is not always necessary to achieve good results. The speed and simplicity of analysis of the Echo MS platform make it an attractive approach for high turnaround bioanalytical laboratories.

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  • Pharma Pharma
  • Technical Notes Technical Notes
  • New

Ultra-fast, accurate and simultaneous quantification of ritonavir and lopinavir in human plasma

The Echo MS system redefines quantitative mass spectrometry throughput. Here, the system delivers very sensitive, accurate and reproducible results for the simultaneous quantitative analysis of 2 protease inhibitors in human plasma. The very short analysis time (3 sec/sample) and method robustness enable scaling up the number of samples for such quantitative analysis.

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  • Synthetic biology Synthetic biology
  • Technical Notes Technical Notes

Rapid quantitative analysis of fermentation broth samples to assess efficiency of engineered yeast strain turnover

In the field of synthetic biology, evaluation of the productivity of thousands of microbe strains for production of a target compound in a very short time is critically important. Here the Echo MS system is used to rapidly analyze levels of a peptide therapeutic in a common fermentation broth, showing the potential impact of this analytical platform on strain selection turnaround time in addressing this bottleneck.

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SCIEX support is the single destination for your mass spectrometry questions.

We aim to fully assist you with virtually every application of our instruments, helping you to get the most out of your lab resources and assets. Maximize your productivity, increase your uptime and accelerate the quality of your results with the SCIEX Now support network – the only team that can deliver all the support your lab needs.

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Learning Hub

Learning Hub success programs provide LC-MS and CE training customized to meet your exact needs.

With a selection of training methods and certifications available, you can build a mass spectrometry program that is most suited to your lab and users.

Starting with a clear understanding of your desired learning outcomes, we aim to help you improve lab productivity and consistency by designing and delivering a program that is focused on knowledge advancement and retention.

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