Biopharma

On-demand/remote

#022 In depth-characterization of a mAb combined with a routine multiple-attribute methodology (MAM) using a novel fragmentation type

Giulia Calloni* [1]; Sibylle Heidelberger [2]; Zoe Zhang [3]; Kerstin Pohl [3]
[1] SCIEX Germany; [2] SCIEX United Kingdom; [3] SCIEX

#028 Profiling and characterization of charge heterogeneity of biologics using capillary electrophoresis and mass spectrometry

Fang Wang; Zuzana Demianova; Peter Holper; Sahana Mollah*
SCIEX

#139 A tool for automated determination and profiling of therapeutic oligonucleotide impurities and metabolites in LC-HRMS data

Eva Duchoslav; Harini Kaluarachchi; Lyle Burton; Thanh Ngu; Peter Liuni*; Jason Causon
SCIEX

#246 Sensitivity improvement on megadalton protein measurement

Feng Zhong*; Mircea Guna; Igor Chernushevich; Bill Loyd; Doug Simmons; Pavel Ryumin
SCIEX

#569 Method development of a simple and rapid MS analysis of oligonucleotides with novel acoustic ejection mass spectrometry (AEMS)

Kaoru Karasawa*
SCIEX Japan

#645 Multi-attribute monitoring of monoclonal antibodies by icIEF-MS

Scott Mack*; Maggie Ostrowski; Hongfeng Yin; Erik Gentalen
SCIEX/Intabio

Monday, November 1

#240 Novel on-chip nebulizer for reliable ESI and icIEF-MS characterization of biopharmaceuticals

Wes Chang* [1]; Wei Chen [1]; Mariam Elnaggar [1]; Don Arnold [2]; Scott Mack [1]; Hongfeng Yin [1]; Erik Gentalen [1]
[1] SCIEX/Intabio; [2] Veristad

#284 A novel fragmentation-based multiple attribute methodology (MAM) for AAV8 capsid protein analysis

Lei Xiong*; Zoe Zhang; Fang Wang; Zhengwei Chen; Kerstin Pohl
SCIEX

#286 Comprehensive high-resolution MS workflow for quantification of intact biotherapeutic proteins

Haichuan Liu*; Lei Xiong; Zoe Zhang; Eshani Nandita
SCIEX

Tuesday, November 2

2:50-3:10 p.m. oral presentation Advancing electron activated dissociation (EAD) in a data-dependent acquisition (DDA) method for improved biotherapeutics characterization

Zhengwei Chen*; Zoe Zhang; Kerstin Pohl; Lei Xiong
SCIEX

#147 Post-translational modification (PTM) profiling on fusion protein aflibercept using a novel fragmentation technique

Xuezhi Bi* [1]; Zoe Zhang [2]
[1] Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore; [2] SCIEX

#155 Characterization of complex glycosylation patterns using a new QTOF mass spectrometer with electron activated fragmentation

Lyle Burton [1]; Bryce Young* [1]; Takashi Baba [1]; Amy Claydon [2]; Stefano Gotta [3]; Zoe Zhang [1]
[1] SCIEX; [2] Genedata Ltd, United Kingdom; [3] Genedata AG, Switzerland

#270 Comparative analysis of intact AAV8 capsid proteins derived from SF9 and HEK293 cell lines

Mallory Heather [1]; Zhang Jason [1]; Lei Xiong [2]; Kerstin Pohl [2]; Dilipkumar Reddy* [2]
[1] Luye Gene Leap BIO; [2] SCIEX

Wednesday, November 3

#251 Applications of electron activated dissociation for next-generation biotherapeutic characterization

Andrew D. Mahan* [1]; Hirsh Nanda [1]; Zoe Zhang [2]; Claire Bramwell [3]; Fang Wang [2]; Elliott Jones [2]
[1] Janssen Research & Development, The Janssen Pharmaceutical Companies of Johnson & Johnson; [2] SCIEX; [3] Protein Metric Inc.

Thursday, November 4

8:50-9:10 a.m. oral presentation Electron activated dissociation in a quadrupole TOF mass spectrometer empowered by Zeno trap pulsing

Takashi Baba*; Pavel Ryumin; Eva Duchoslav; Anjali Chelur; Bill Loyd; Igor Chernushevich; Jason Causon; José Castro-Perez
SCIEX

#005 A novel alternative fragmentation approach for comprehensive glycopeptide analysis of therapeutic proteins

Sibylle Heidelberger* [1]; Fang Wang [2]; Jenny Albanese [2]; Zoe Zhang [2]; Pavel Ryumin [2]; Takashi Baba [2]; Jason Causon [2]; Bill Loyd [2]; Kerstin Pohl [2]
[1] SCIEX United Kingdom; [2] SCIEX

#047 Novel methods for increasing throughput and detection of acoustic ejection mass spectrometry (AEMS)

Neal Liddle*; Rahul Baghla; Chang Liu
SCIEX

#061 Evaluation of a highly sensitive single platform method for quantification of crucial components from cell culture media (CCM) by LC-MS/MS

Mariateresa Maldini* [1]; Eshani Nandita [2]; Zuzana Demianova [2]
[1] SCIEX Italy; [2] SCIEX

#242 Sub ng/mL quantification and characterization of oligonucleotides in plasma using microflow LC coupled to a novel QTOF mass spectrometer

Remco Van Soest*; Eshani Nandita; Kerstin Pohl; Elliott Jones
SCIEX

#246 A highly sensitive and automated workflow for the ID and relative quantification of oligonucleotide impurities and metabolites

Todd Stawicki*; Remco Van Soest; Kerstin Pohl
SCIEX

#260 Improving peptide quantification using a high-resolution QTOF mass spectrometer

Wen Jin*; Suya Liu; Leroi Desouza; Doug Simmons
SCIEX

#262 Sensitive quantification of human glucagon-like peptide 1 (GLP-1) analogue in plasma using LC-MS/MS

Elliott Jones* [1]; John Thorup [2]; Eshani Nandita [1]
[1] SCIEX; [2] University of California Berkeley

#263 Enhanced selectivity and sensitivity for peptide quantification in a complex matrix using high-resolution LC-MS/MS workflow

Shane Needham* [1]; Eshani Nandita [2]; Lei Xiong [2]; Elliott Jones [2]; Zoe Zhang [2]; Kerstin Pohl [2]
[1] Alturas Analytics Inc.; [2] SCIEX

#264 High-resolution LC-MS/MS workflow for quantification of disulfide-bridged cyclic peptide in rat plasma using electron activated dissociation (EAD)

Eshani Nandita*; Lei Xiong; Elliott Jones
SCIEX

#270 The characterization and quantification of the cyclic peptide Oxytocin using Zeno CID and Zeno EAD

Jason Causon; Naomi Diaz*; José Castro-Perez
SCIEX

Clinical research

On-demand/remote

#044 Machine learning to reduce manual correction of LC-MS peak integrations

Lyle Burton*; Gillian Brooks
SCIEX

Food and beverage

On-demand/remote

#044 Machine learning to reduce manual correction of LC-MS peak integrations

Lyle Burton*; Gillian Brooks
SCIEX

Wednesday, November 3

#351 Highly sensitive quantification and selective identification of pesticides in food with Zeno MRMHR and electron activated dissociation

Amadeo Rodriguez Fernandez-Alba [1]; Robert A. Di Lorenzo* [2]; Lukasz Rajski [1]; Jianru Stahl-Zeng [3]; Jason Causon [2]
[1] EURL-FV, Universidad de Almeria, Spain; [2] SCIEX; [3] SCIEX Germany

Life science research

On-demand/remote

#110 Leveraging a higher duty cycle DIA acquisition on a novel QTOF for enhanced proteomics analysis

Ihor Batruch*; Yves LeBlanc; Jason Causon; Naomi Diaz; Tatjana Talamantes; Anjali Chelur; Nic G. Bloomfield; Stephen Tate; José Castro-Perez
SCIEX

#112 Using state-of-the-art data independent acquisition (DIA) methods for protein identification in complex mixtures

Stephen Tate*; Yves LeBlanc
SCIEX

#265 Improved separation and sensitivity of sialylated glycopeptide isomers on reversed phase LC-MS/MS

Suya Liu*; Doug Simmons; Pavel Ryumin; Takashi Baba
SCIEX

#405 Recent advances in electrospray sampling efficiency and implications for LC-MS

Leigh Bedford*; Bradley B. Schneider; Hassan Javaheri; Thomas R. Covey
SCIEX

#408 Ion guide for improved atmosphere to mass spectrometer vacuum ion transfer

Hassan Javaheri*; Bradley B. Schneider
SCIEX

#522 Separation of hexose phosphate isomers using differential mobility spectrometry

Catherine S. Lane* [1]; Denise Mehl [2]; Arno Van Rooij [3]; Alain J. Van Gool [3]; Richard J. T. Rodenburg [3]; Dirk J. Lefeber [3]; Marek J. Noga [3]
[1] SCIEX United Kingdom; [2] SCIEX Germany; [3] Radboudumc, Netherlands

#543 Significant advances in metabolomics using a novel QTOF instrument with improved sensitivity

Kranthi Chebrolu*; Christie Hunter; Jason Causon
SCIEX

#544 Rapid analysis and interpretation of metabolomics data independent acquisition (DIA) data using a cloud-based processing pipeline

Arianna I. Jones*; Alexandra Antonoplis; Jason Causon; Christie Hunter
SCIEX

#694 Impacts of nanoflow column length and core-shell based chromatographic phases on protein and peptide identifications in DDA workflows

Alexandra Antonoplis* [1]; Jason Anspach [2]; Christie Hunter [1]
[1] SCIEX; [2] Phenomenex

Tuesday, November 2

3:10-3:30 p.m. oral presentation High-throughput metabolite quantification for synthetic biology using the Echo® MS system

Mackenzie J. Pearson* [1]; Rahul Baghla [1]; Robert Proos [1]; Neal Liddle [1]; Baljit Ubhi [1]; Mona Elbadawi-Sidhu [2]; Tony Wu [2]; Chia-Wei Lu [2]; Hanxiao Jiang [2]
[1] SCIEX; [2] Amyris

Wednesday, November 3

#234 A high-throughput large scale targeted MRM method for serum metabolite profiling

Robert Proos*; Kranthi Chebrolu; Christie Hunter
SCIEX

#245 Discovery phosphoproteomics using electron activated dissociation and high sensitivity MS/MS on a novel QTOF system

Randy J. Arnold* [1]; Uma Aryal [2]; Rodrigo Mohallem [2]; Alexandra Antonoplis [1]; Arianna Jones [1]; Christie Hunter [1]
[1] SCIEX; [2] Purdue University

Thursday, November 4

9:50-10:10 a.m. oral presentation Using EIEIO as a novel fragmentation technique for complete lipid characterization in a complex matrix

Mackenzie J. Pearson*; Paul Norris; Christie Hunter; Takashi Baba
SCIEX

#047 Novel methods for increasing throughput and detection of acoustic ejection mass spectrometry (AEMS)

Neal Liddle*; Rahul Baghla; Chang Liu
SCIEX

Pharma

On-demand/remote

#129 True high throughput analysis of transporter activity analysis

Rolf Kern*; Rahul Baghla
SCIEX

#139 A tool for automated determination and profiling of therapeutic oligonucleotide impurities and metabolites in LC-HRMS data

Eva Duchoslav; Harini Kaluarachchi; Lyle Burton; Thanh Ngu; Peter Liuni*; Jason Causon
SCIEX

#757 Ultrafast bioanalytical analysis using the Echo® MS system - two case studies

Rahul Baghla*; Rolf Kern
SCIEX

Monday, November 1

9:50-10:10 a.m. oral presentation Automated mass spectra comparison algorithm for high-throughput compound QC applications

Chang Liu* [1]; Gordana Ivosev [1]; Neal Liddle [1]; Alandra Quinn [2]; Jeff Chin [2]; Thomas R. Covey [1]; Hui Zhang [2]
[1] SCIEX; [2] Pfizer

#027 A novel high duty cycle data independent technique for metabolite identification in drug metabolism

José Castro-Perez* [1]; Jason Causon [1]; Christopher Konchansky [2]; Kevin P. Bateman [2]
[1] SCIEX; [2] Merck & Co.

#149 Background ion detection algorithm in ultra-high-throughput QC with mass spectrometry

Gordana Ivosev* [1]; Chang Liu [1]; Alandra Quinn [2]; Jeff Chin [2]; Stephen Tate [1]; Thomas R Covey [1]; Hui Zhang [2]
[1] SCIEX; [2] Pfizer

Wednesday, November 3

#135 Fluid dynamics of the open port interface for high-speed nanoliter volume sampling mass spectrometry

Chang Liu [1]; Gary J. Van Berkel [2]; Peter Kovarik [1]; Blair Perot [3]; Venkatesh Inguva [3]; Thomas R. Covey* [1]
[1] SCIEX; [2] Van Berkel Ventures, LLC; [3] University of Massachusetts Amherst

Thursday, November 4

#045 High-throughput compound QC workflow with acoustic ejection mass spectrometry

Chang Liu [1]; Cristiano Veiga [1]; Alandra Quinn [2]; Jeff Chin [2]; Thomas R. Covey [1]; Hui Zhang* [2]
[1] SCIEX; [2] Pfizer

#047 Novel methods for increasing throughput and detection of acoustic ejection mass spectrometry (AEMS)

Neal Liddle*; Rahul Baghla; Chang Liu
SCIEX

#260 Improving peptide quantification using a high-resolution QTOF mass spectrometer

Wen Jin*; Suya Liu; Leroi Desouza; Doug Simmons
SCIEX

Technology

On-demand/remote

#379 Automated approach to optimize differential mobility spectrometry separations

Eva Duchoslav*; Leigh Bedford; Yves LeBlanc; Bradley B. Schneider
SCIEX

#405 Recent advances in electrospray sampling efficiency and implications for LC-MS

Leigh Bedford*; Bradley B. Schneider; Hassan Javaheri; Thomas R. Covey
SCIEX

#408 Ion guide for improved atmosphere to mass spectrometer vacuum ion transfer

Hassan Javaheri*; Bradley B. Schneider
SCIEX

#411 Electron activated dissociation device with ion isolation functionality in mass spectrometry

Grant Godbehere*; Takashi Baba
SCIEX

#440 Acoustic ejection mass spectrometry (AEMS) / differential ion mobility for ultra-high throughput mass spectrometry

Leigh Bedford; Bradley B. Schneider*; Eva Duchoslav; Aaron Stella; Subhasish Pukayastha; Chang Liu;Thomas R. Covey
SCIEX

Monday, November 1

#167 Qualitative flexibility combined with quantitative power – a technological advancement in MS/MS sensitivity and electron-based fragmentation

Robert A. Di Lorenzo*; Jason Causon; Takashi Baba; Robert Haufler
SCIEX

Thursday, November 4

#047 Novel methods for increasing throughput and detection of acoustic ejection mass spectrometry (AEMS)

Neal Liddle*; Rahul Baghla; Chang Liu
SCIEX

 

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