Whatever your analytical approach in veterinary drug testing, our team is eager to support your lab for reliable success and constant results.
SCIEX - providing the sensitivity you need.
Veterinary drug residue testing
Explore the latest and trending topics
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Technical note
Decision limit and detection capability CCα and CCβ
Discover automatic calculation of CCalpha and CCbeta for both non-permitted and permitted substances at the same time and benefit from automatic flagging of samples with analyte concentrations above CCalpha and/or CCbeta within SCIEXOS.
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Publication
Screening of 152 Veterinary Drug Residues in Animal Source Foods by LC–MS/MS, Multilaboratory Validation Study: Final Action 2020.04
AOAC has approved the method for Final Action status. The interlaboratory reproducibility determined for this method met the acceptance criteria defined in AOAC Standard Method Performance Requirement (SMPR) 2018.010.
Veterinary drug residue analysis for safer animal products
Veterinary drugs administered to animals can leave residues in animal products such as meat, fish, crustaceans, milk, honey and eggs. Maximum residue limits (MRLs) are established by regulatory authorities to minimize the adverse health risk to consumers.
Compound classes that are commonly analysed in veterinary drug testing are antibiotics, antiparasitics, antifungals, antivirals, anthelmintics, as well as corticosteroids, growth promoters and nonsteroidal anti-inflammatory drugs (NSAIDs). These large and diverse analyte panels often include both the parent compounds and their metabolites. The fast MRM acquisition time of SCIEX instruments - low dwell and pause times - allow for large analyte panels to be quantified with sufficient data points across the chromatographic peak while maintaining good data quality.
Detecting and quantifying veterinary drug residues in food matrices can be challenging due to low concentrations and matrix interferences. SCIEX provides technology to achieve the high sensitivity needed to meet regulatory guidelines with triple quadrupole instruments known to perform with exceptional robustness.
Veterinary drug analysis in dirty samples is challenging due to matrix background interferences. Increase your quantititon confidence using two analysis methods with enhanced specificity: MRM3 on QTRAP instruments and MRMHR on QTOF instruments.
Veterinary drug analysis:
SCIEX 7500 system vs 7500+ system
Claudia Ancillotti
Method Development Manager, Biochemie Lab
Highlighted workflow
Quantitation veterinary drug residues
Due to the wide variety of animal-derived foods, complex sample matrices, multiple types of veterinary drugs and large differences in physical and chemical properties, food safety testing remains challenging for animal products. SCIEX triple quadrupole methods aim to provide a complete solution for efficient testing for veterinary drugs and illegally added drugs in animal-derived foods.
The use of veterinary drugs is commonly regulated in two ways:
- Permitted substances and
- Prohibited substances.
As for permitted substances, many countries have set MRL values. For prohibited substances, it is crucial for testing laboratories to meet minimum method performance requirements (MMPR). The SCIEX 7500+ triple quadrupole system provides the necessary sensitivity to meet both aspects for the strictest requirements globally.
Featured veterinary drug testing resources - high and ultra-high sensitivity
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Technical note
Leveraging sensitivity to simplify sample preparation and improve laboratory productivity for contaminant analysis
Here, a single sample preparation based on a new QuEChERSR was used to analyze hundreds of pesticides, veterinary drugs and mycotoxins in different food and feed matrices using the SCIEX 7500 system. pesticides, veterinary drugs and mycotoxins can be analyzed together in a single large panel method.
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Technical note
Ultra-high sensitivity quantification of veterinary drug residues in products of animal origin
Demonstrated ability to analyze more than 180 relevant compounds in pork, chicken and milk food matrices, at concentrations as low as 0.01 µg/kg in pork and chicken and 0.005 µg/kg in milk. The use of quantifier and qualifier transitions allows for the use of ion ratios to increase specificity of the analysis. Linear dynamic ranges span up to 4 orders of magnitude.
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Technical note
High sensitivity and dynamic range for veterinary drugs analysis with the SCIEX Triple Quad™ 5500+ System − QTRAP® Ready
A mixture of 218 veterinary drugs, with different compound classes, like Corticoids, Quinolones, Sulfamides, Macrolides, Tetracyclines and many others, are included in this study.
Veterinary drug residue testing
Solution
Achieve crucial performance criteria:
- Targeted analysis for large panels with fast switching electronics
- Easy to learn acquisition and processing software
- Outstanding service to keep you up and running
SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
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SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
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Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
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All resources
Explore more methods focused on smaller veterinary drug groups or high-resolution mass spectrometry.
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Technical note
Rapid, sensitive, quantitation method for chloramphenicol in meat using SCIEX 3500 system
The method of analysis for chloramphenicol in meat described here was developed and performed according to the criteria established by the EC Commission Decision 657/2002.
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Technical note
Rapid determination of nitrofuran metabolite residues in aquatic products
The method easily meets the quantification limit requirements of GBT21311-2007, Ministry of Agriculture 783-1-2006 and 781-4-2006.
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Technical note
Rapid determination of sulfonamide and quinolone residues in aquatic products
The basis of existing sulfonamides detection in China is Ministry of Agriculture 1025-23-2008, with a quantification limit of 0.5 μg/kg. The basis of quinolone detection is GB 20366-2006, with a quantification limit of 1.0 μg/kg. Both of these drugs are addressed by Ministry of Agriculture Announcement No. 1077-1-2008, which requires a quantification limit of 2.0 μg/kg.
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Technical note
Simultaneous quantification of aminoglycoside antibiotics in milk using the SCIEX Triple Quad™ 3500 LC-MS/MS System
SCIEX Triple Quad 3500 System achieved a quantitative and qualitative determination at ~100x below the MRL level. The method performed in accordance with 2002/657/EC directive commission.
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Technical note
Analysis of metronidazole and ronidazole in milk using the SCIEX Triple Quad™ 3500 LC-MS/MS System
The developed method was validated as per the guidance found in the Commission decision 2002/657/EC
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Technical note
Quantification of multiple antibiotics in milk using the SCIEX Triple Quad™ 3500 LC-MS/MS System
The method developed as per 2002/657/EC directive recommendations showed acceptable accuracies (80%-120%) for analysis in matrix samples.
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Technical note
Analysis of nitrofuran metabolites in honey using the SCIEX Triple Quad 3500 system
A LC-MS/MS method developed on SCIEX Triple Quad™ 3500 described here for the quantitation of nitrofuran metabolites in honey was found to meet the regulatory requirements of 1μg/kg.
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Technical note
Quantitation method for nitrofuran metabolites in milk using SCIEX triple quad™ 3500 system
The method allows high throughput, selective, rapid and sensitive LC-MS/MS identification and quantitation of banned Nitrofuran metabolites meeting EU MRPL of 1.0 µg/kg.
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Technical note
Analysis of streptomycin and its metabolite in honey using the SCIEX Triple Quad 3500 system
Better separation and reproducibility of Streptomycin and Dihydrostreptomycin was achived using ion pairing reagent in Honey sample. The Minimum Required Performance Limit (MRPL) for Streptomycin and Dihydrostreptomycin in Honey was 10µg/kg.
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Technical note
Analysis of chloramphenicol in honey
The method development was performed to meet the minimum required performance limit (MRPL) of 0.3 ng/mL as established by the EC Commission Decision 657/2002.
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Technical note
Quantitation of chloramphenicol in milk using SCIEX triple quad 3500 LC-MS/MS system
The Commission Decision 2002/657/EC Annexure II requires control of CAP residues in edible tissues, meat, seafood, eggs, honey, milk, and milk products. The Minimum Required Performance Limit (MRPL) for CAP in milk was 0.3µg/kg.
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Technical note
Analysis of streptomycin and its metabolite in milk using the SCIEX 3500 system
The results qualified the method for the quantification and confirmation of the analytes in milk at concentrations inferior to the established Maximum Residue limit (200ng/ml).
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Technical note
Analysis of sulfonamides in milk using the SCIEX 3500 System
Nine sulfonamide analytes were determined with a single extraction and the proposed method could be applied in routine analysis.
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Technical note
Analysis of sulfonamides in honey using the SCIEX 3500 system
Method for all the nine sulfonamides (Sulfamerazine, Sulfadiazine, Sulfamethazine, Sulfadimethoxine, Sulfamethoxypyridazine, Sulfamethoxazole, Sulfadoxine, Sulfathiazole, and Sulfapyridine) with minimum required performance limit (10.0 ng/ml).
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Technical note
Combining non-targeted SWATH® MS/MSALL Acquisition with Highly Selective MRMHR for the analysis of veterinary drugs in tissue using the SCIEX X500R system
A versatile and sensitive workflow on the SCIEX X500R QTOF system which combines a non-targeted screening workflow using SWATH Acquisition looped with highly selective MRMHR acquisition for confident identification and targeted quantitation.
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Technical note
Simultaneous determination of 88 veterinary drug residues in pork liver using LC-MS/MS
A panel of 88 chemically diverse veterinary drugs was effectively monitored in both positive and negative ion modes on the SCIEX QTRAP 4500 system.