ASMS 2022 Posters

Biopharma

Monday, June 6

#016 Comprehensive mapping of disulfide linkages in etanercept using an electron activated dissociation (EAD) based LC-MS/MS methodology

Zhengwei Chen*; Lei Xiong
SCIEX

#067 A novel fragmentation technology allows for in-depth glycopeptide characterization in glycoproteins

Jenny Albanese*; Zoe Zhang
SCIEX

#340 A comprehensive method for quantification and in-depth profiling of secreted metabolites from human adipose stem cells

Marialuce Maldini*¹; Valentina Bina²; Giulia Gastaldi²; Eshani Nandita³
¹SCIEX Italy; ²Department of Molecular Medicine, University of Pavia, Italy; ³SCIEX

#375 Low-pg/mL quantification of complex disulfide-rich peptides in rat plasma using microflow LC-MS/MS

Eshani Nandita*; Remco Van Soest; Zoe Zhang; Elliott Jones
SCIEX

#376 An in-sample calibration evaluation approach for the quantification of peptides using an LC-MS/MS workflow

Cathy Lane*¹; Sebastiaan Bijttebier²; Lieve Dillen²; Eshani Nandita³
¹SCIEX United Kingdom; ²Janssen Research and Development, Belgium; ³SCIEX

#478 Intact LC-MS analysis and peptide mapping of recombinant adeno associated virus (rAAV) capsid proteins

Haichuan Liu; Kerstin Pohl; Elliott Jones*; Zoe Zhang
SCIEX

Tuesday, June 7

#023 Utilizing an easily tunable declustering potential for the removal of adduct ions on intact biotherapeutics

Greg T Roman*; Dilip Kumar Reddy Kandula; Lei Xiong
SCIEX

Wednesday, June 8

3:30 p.m. Oral presentation Qualitative and targeted analysis of cell culture media components using accurate mass spectrometry

Marialuce Maldini¹; Antonella Chiapparino²; Eshani Nandita³
¹SCIEX Italy; ²SCIEX Germany; ³SCIEX

#423 Sensitive signature peptide quantification in a complex matrix using accurate mass spectrometry

Xin Zhang*; Eshani Nandita; Lei Xiong; Zoe Zhang; Elliott Jones
SCIEX

#448 Demonstration of an improved multi-attribute methodology (MAM) using alternative fragmentation to enhance the identification of product quality attributes (PQAs)

Haichuan Liu¹; Ricardo A. Gomes^{2, 3}; Zoe Zhang¹; Kerstin Pohl*¹
¹SCIEX; ²iBET, Instituto de Biologia Experimental e Tecnológica, Portugal; ³ITQB, Instituto de Tecnologia Química e Biológica António Xavier, Portugal

#449 In-depth characterization of SARS-CoV-2 and mutant N501Y spike proteins

Rachel Rowlinson¹; Raquel Faba1; Mark Abbott¹; Kerstin Pohl²; Haichuan Liu²; Sibylle Heidelberger*³
¹Peak Proteins, United Kingdom; ²SCIEX; ³SCIEX United Kingdom

Thursday, June 9

#185 Comprehensive site-specific glycan profiling of a protein-based flu vaccine using electron-activated dissociation (EAD)

Andrew D Mahan*¹; Zoe Zhang²; Hirsh Nanda¹
¹Janssen Research & Development, The Janssen Pharmaceutical Companies of Johnson & Johnson; ²SCIEX

#403 Evaluation of electron kinetic energies for advanced characterization of protein therapeutics using electron-activated dissociation (EAD)

Haichuan Liu*¹; Xuezhi Bi²; Elliott Jones¹; Zoe Zhang¹
¹SCIEX; ²Bioprocessing Technology Institute, Singapore

#408 Comprehensive characterization of complex linkage structures in bispecific monclonal antibody (mAb) using electron activated dissociation (EAD)

Andrew D. Mahan¹; Hirsh Nanda1; Zoe Zhang*²
¹Janssen; ²SCIEX

#416 Comprehensive characterization of trastuzumab using chip-based integrated icIEF-MS technology and correlation of intact and bottom-up peptide mapping analysis

Scott Mack*; Mariam El Neggar; Hongfeng Yin; Rita Nichiporuk; Zoe Zhang; Elliott Jones; Maggie Ostrowski
SCIEX

Environmental and industrial

Monday, June 6

#002 Detection of 23 sensitizing and carcinogenic dyes in textiles by LC-MS/MS

Qing Liu¹; Xiong²; Xengxing¹; Zong Yang¹; Bingjie Liu¹; Lihai Guo¹
¹SCIEX China; ²Food Inspection and Testing, China

#143 Use of electron-activated dissociation (EAD) on the ZenoTOF 7600 system to elucidate PFAS structures

Karl Oetjen; Craig M. Butt; Megumi Shimizu; Diana Tran; Simon Roberts*
SCIEX

#193 Acoustic Ejection Mass Spectrometry (AEMS) for ultra-fast quantification of 17 drugs in sewage

Zhiyuan Li
SCIEX China

Tuesday, June 7

#073 Identification of antibiotic degradation products with UPLC-QTOF system

Xi Chen*¹; Xianglong Zhao1; Bingjie Liu¹; Lihai Guo¹; Bo Lai²; Jianfei Yan²; Marc Browning³
¹SCIEX China; ²Sichuan University, China; ³SCIEX

#086 Identification and quantification of 12 drugs in sewage using on-line solid phase extraction on the SCIEX Triple Quad 4500 system

Chong Zhang*; Xiaojie Sun; Bingjie Liu; Lihai Guo
SCIEX China

Wednesday, June 8

#167 Sensitive and robust quantification of 15 common UV filters in commercial sunscreens

Qing Liu¹; Xiong²; Xengxing¹; Zong Yang¹; Bingjie Liu¹; Lihai Guo¹
¹SCIEX China; ²Food Inspection and Testing, China

Thursday, June 9

9:50 a.m. Oral Presentation Improved compound identification in non-target screening

David Cox*; Craig M. Butt; Janna Anichina; Adrian M. Taylor
SCIEX

Food and beverage

Monday, June 6

#322 Using Scout triggered MRM to improve allergen screening

Holly Lee*; Simon C. Roberts; David Cox
SCIEX

Tuesday, June 7

#105 Analysis of the residues of herbicides and metabolites in tea and honey

Mu Pengqian; Huan Yu; Li Xinglin; Matthew Skaley*; Yang Zong; Liu Bingxie; Guo Lihai
SCIEX China

Wednesday, June 8

#151 Simultaneous determination of 49 amino acids, B vitamins, flavonoids and phenolic acids in vegetables by ultra-performance liquid chromatography–tandem mass spectrometry

Liuqing Zhao¹; Zeying He²; Zong Yang¹; Bingjie Liu¹; Lihai Guo¹
¹SCIEX China; ²Ministry of Agriculture, Agro-Environmental Protection Institute, China

#153 Identification of peach species using the X500R QTOF system

Gu Ye¹; Mu Pengqian*²; Yang Zong²; Liu Bingjie²; Guo Lihai²
¹Wuxi Food Safety Inspection and Test Center, China; ²SCIEX China

#154 Application of the X500R QTOF system in new psychoactive substances in electronic cigarettes

Mu Pengqian; Zhang Xiaogang*; Yang Zong; Liu Bingxie; Guo Lihai
SCIEX China

Thursday, June 9

9:50 a.m. Oral Presentation Improved compound identification in non-target screening

David Cox*; Craig M. Butt; Janna Anichina; Adrian M. Taylor
SCIEX

#135 Ultra-high sensitivity quantification of veterinary drug residues in products of animal origin

Jack Steed¹; Yoann Fillatre²; Michael Scherer³; Aline Staub Sporri⁴; Grégoire Bonvin⁴; Jianru Stahl-Zeng*⁵
¹SCIEX United Kingdom; ²SCIEX France; ³SCIEX Switzerland; ⁴Official Food Control Authority and Veterinary Affairs of Geneva; ⁵SCIEX Germany

#136 An LC-MS/MS method for the rapid screening and quantitative analysis of 500 types of pesticide and metabolite residues with the ZenoTOF 7600 system

Jingran Zhang*¹; Rob Di Lorenzo²; Xiaojie Sun¹; Liu Bingxie¹; Guo Lihai¹
¹SCIEX China; ²SCIEX

Forensic

Monday, June 6

#182 Establishing a qualitative and quantitative method for 803 poisons in blood and urine using the ZenoTOF 7600 system

Linlin Guo; Xiaojie Sun; Bingjie Liu; Lihai Guo
SCIEX China

#193 Acoustic Ejection Mass Spectrometry (AEMS) for ultra-fast quantification of 17 drugs in sewage

Zhiyuan Li
SCIEX China

Tuesday, June 7

#086 Identification and quantification of 12 drugs in sewage using on-line solid phase extraction on the SCIEX Triple Quad 4500 system

Chong Zhang; Xiaojie Sun; Bingjie Liu; Lihai Guo
SCIEX China

Wednesday, June 8

#154 Application of the X500R QTOF system in new psychoactive substances in electronic cigarettes

Mu Pengqian; Zhang Xiaogang*; Yang Zong; Liu Bingxie; Guo Lihai
SCIEX China

Life science research

Monday, June 6

#076 Accelerating DIA studies with fast microflow LC and Zeno SWATH acquisition

Christie Hunter*; Alexandra Antonoplis
SCIEX

#077 Improved data-independent acquisition (DIA) and data-dependent acquisition (DDA) performance on low-level proteomic samples using a novel Zeno trap

Ihor Batruch*; Stephen Tate; Nic Bloomfield; Anjali Chelur; Jose Castro-Perez
SCIEX

#338 Determination of 90 amine-containing metabolites in biological samples using the SCIEX Triple Quad 4500 system

Huimin Chen*; Zhimin Long; Lihai Guo
SCIEX China

#406 Characterization of the multi-acetylated sites of human histone 2A variants by capillary electrophoresis and electrospray ionization mass spectrometry (CESI-MS)

Zhichang Yang*¹; Zuzana Demianova¹; Klaus Faserl²; Bettina Sarg²; Sahana Mollah¹; Herbert Lindner²
¹SCIEX; ²Medizinische Universität Innsbruck, Austria

Tuesday, June 7

#386 A 3D chemical peak finder for comprehensive small molecule identification

Pradeep Narayanaswamy*¹; Eva Duchoslav²
¹SCIEX Singapore; ²SCIEX

#445 Analysis of post-translational modifications using fast electron-activated dissociation (EAD)

Alexandra Antonoplis*¹; Christie Hunter¹; Nick Morrice²
¹SCIEX; ²SCIEX United Kingdom

Wednesday, June 8

#237 Mass spectrometer robustness improvement with a quadrupole ion guide bandpass filter

Bradley B. Schneider; Yang Kang; Leigh Bedford; Ian Moore; James Hager; Mircea Guna; Chang Liu*
SCIEX

Thursday, June 9

#394 Global metabolite profiling of leaves and flowers of Ocimum basilicum L. grown in greenhouse under different light wavelengths

Kranthi Chebrolu*¹; Marialuce Maldini²; Paola Montoro³; Luigi Aquino⁴; Christie Hunter¹
¹SCIEX; ²SCIEX Italy; ³University of Salerno, Italy; ⁴ENAA, Italy

#472 Zeno MS/MS significantly improves quantification for iTRAQ reagent-labeled proteomic samples

Randy J. Arnold*¹; Alexandra Antonoplis¹; Christie Hunter¹; Nick Morrice²
¹SCIEX; ²SCIEX United Kingdom

Pharma

Monday, June 6

#098 Comprehensive metabolite characterization using orthogonal MS/MS data

Eva Duchoslav*; Disha Thakkar; Yves Le Blanc; Jason Causon
SCIEX

#431 Quantification of nitrosamines and related impurities in multiple drug products by LC-MS

Jack Steed*¹; Jianru Stahl-Zeng²; Ferran Sanchez³; Santosh Kapil Kumar Gorti⁴; Dilip Kumar Reddy Kandula⁴
¹SCIEX United Kingdom; ²SCIEX Germany; ³SCIEX Spain; ⁴SCIEX

#447 Ultra-sensitive quantification of the low-level inhalant drugs fluticasone propionate and salmeterol xinafoate in human plasma

Rahul Baghla*; Ian Moore; Santosh Kapil Kumar Gorti
SCIEX

Tuesday, June 7

#258 Two approaches for MRM³ data acquisition using the SCIEX 7500 system

Shaokun Pang
SCIEX

Wednesday, June 8

#145 Design of a non-LC based affinity selection MS breadboard system targeting 100,000 compounds screened/day

Thomas R. Covey*¹; Chang Liu¹; Peter Kovarik¹; Subhasish Purkayastha¹; Sasi Pillai¹; Gary Van Berkel²; Emmet Welsh³; Jiani Zhao³; Sam Michaels⁴; John Janizewski⁴; Meghav Verma⁴; Jonathan Shrimp⁴; Erik Miller⁵
¹SCIEX; ²Van Berkel Ventures; ³Phenomenex; ⁴National Center For Advancing Translational Sciences; ⁵IMI Adaptas