Glycosylation is potentially the most important biotherapeutic critical quality attribute (CQA) in the discovery and development pipeline as it directly impacts binding capabilities, efficacy, immunogenicity, and clearance.
Glycan analysis is crucial to overall biotherapeutic safety. Take for example research scientists performing clone selection. Analytical development researchers running glycan characterization and QA/QC analysts responsible for lost release.
In all these scenarios, determining the exact glycans on large biotherapeutics can be difficult due to their diversity. Different glycan analysis strategies are being applied with varying degrees of success, but few can provide the depth of characterization required with a simple, fast and accurate assay. The downside is that many labs are struggling to cope with the increasing workload.
Accelerate Biotherapeutic Glycan Analysis
With SCIEX fast glycan CE solutions, you can now determine what type and how many glycans are on your large biotherapeutics, up to 2x faster than traditional HILIC methods, with higher resolution. SCIEX LC-MS and CESI-MS solutions can accurately determine intact and subunit level glycoprotein profiles for comparability reasons, as well as obtain site specific glycan information at the peptide level.
Now you can experience the certainty and simplicity of protein glycosylation analysis with innovative LC-MS, CESI-MS, and CE solutions from SCIEX. It has never been easier to gain a comprehensive analysis of glycans on large biotherapeutics in a single solution – with fast, precise and in-depth characterization:
Whether you are using HILIC or CE to quantitatively determine what glycans are present, performing LC-MS or CESI-MS on intact biotherapeutics to determine the relative presence of glycoforms, or analyzing glycopeptides to identify glycans and their location, we have the right solution for you. Our fast glycan technology as well as our best-in-class mass spec options with BioPharmaView software, will simplify analyses and get you quantitative answers faster.