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The perfect accessory for your Mass Spectrometer
For analysis in areas such as:
Watch the 2016 Inaugural CESI-MS Symposium Webinar's on Demand
To find out how CESI-MS can help you, request your samples to be analyzed now.
Experience the revolutionary ESI-MS approach to discovering previously undetectable characteristics from the minutest amount of precious samples, faster than ever before. Whether using as a standalone capillary electrophoresis instrument or in conjunction with the power of mass spectrometry, the CESI 8000 Plus allows you to concentrate on your science rather than technology. You’ve worked hard to get your sample this far. Get the most from that precious material and hunt down the hidden information you couldn’t see before:
Take control of your PA 800 Plus with Waters Empower 3 Chromatography Data Software (CDS) for data integrity compliance. Reduce regulatory risk and maximize method transfer efficiency with the newly released SCIEX Empower Driver version 1.3.
The CESI 8000 Plus high-performance system delivers fast, efficient and unique separation selectivity with enhanced sensitivity, while simultaneously expanding coverage.
Learn why capillary electrophoresis - mass spectrometry (CE-MS) is an attractive microscale analytical technique for addressing biological questions inherently dealing with low amounts of material.
Simplify the analysis of isobaric compounds inadequately resolved with current methods.
Expanded coverage allows you to see more than ever before.
Reveal hydrophilic charged and polar compounds and increase sensitivity in your metabolome and glycome analysis, not possible with LC methods.
Confidently quantify and characterize proteoform and peptide PTMs, such as those with multiple phosphorylation and glycosylation sites.
|PA 800 Plus CZE Application Guide||10/21/2020|
|Velocity-corrected area calculation: SCIEX PA 800 Plus Empower Driver version 1.3 vs. 32 Karat Software||09/25/2020|
|CE Training Overview 2021||09/24/2020|
|CE Training Overview DE 2021||09/24/2020|
|Comprehensive Analysis of Low Abundant Mannose Glycopeptides in Peptide Mapping of Adalimumab in a Single Run||09/04/2020|
|SDS-MW calibration and molecular weight estimation using the SCIEX PA 800 Plus Empower Driver version 1.3||08/19/2020|
|Optimized digestion procedure and characterization for monoclonal antibodies and proteins by CESI-MS||08/14/2020|
|Meet the Experts: Expand control and flexibility of your CE system with SCIEX Empower Driver v1.3||07/31/2020|
|Comprehensive analysis of low abundant mannose glycopeptides in peptide mapping of adalimumab||07/10/2020|
|Endogenous nucleotides from low numbers of mammalian cells||06/08/2020|
|Identification of multiple phosphorylation sites||05/18/2020|
|CESI 8000 Plus High Performance Separation-Site Planning Guide||04/24/2020|
|CESI 8000 Plus High Performance Separation-ESI Module User Manual||04/14/2020|
|No pressure HPLC||04/13/2020|
|Charge Variant Analysis by CESI-MS||04/07/2020|
|Identifying and Quantifying Aspartate and Iso-Aspartate Isomers||04/06/2020|
|CESI 8000 High Performance Separation - ESI Module||02/15/2020|
|CE Training Overview 2020||01/29/2020|
|CE Kit Brochure||01/22/2020|
|Quick Guide CE Instrument Maintenance||01/14/2020|
|Preparation Scale-Up Of Complex BiologicakSamples For Deep N-Glycomic Analysis By CE-LIF and CESI-MS||12/11/2019|
|SCIEX Capillary Electrophoresis Consumables Guide||09/27/2019|
|Comprehensive Capillary Electrophoresis Training Course||07/26/2019|
|Better Insights into Charge Variants of Therapeutic IgGs||06/21/2019|
|Neutral CESI Electrical Conditioning||06/17/2019|
|Neutral CESI Peptide Separation||06/17/2019|
|Neutral CESI Protein Separation||06/17/2019|
|Neutral CESI Rest||06/17/2019|
|Neutral CESI Washing||06/17/2019|
|Charge Heterogeneity Analysis of Intact Infliximab Using CESI-MS and Neutral OptiMS Cartridge||05/31/2019|
|CESI 8000 Plus High Performance Separation-ESI Module Software Validation Summary||03/20/2019|
|CESI 8000 Plus High Performance Separation-ESI Module System Administration Guide||03/18/2019|
|OptiMS Silica Surface Cartridge Quick Start Guide||03/18/2019|
|Neutral OptiMS Cartridge Quick Start Guide||01/15/2019|
|Environmental Compendium Volume 3||12/10/2018|
|CESI-MS/MS: Quantitation of Highly Polar Pesticides||12/07/2018|
|Charge Variant Assessment of Nanobodies at the Intact Level by CESI-MS||10/24/2018|
|Resolving volume-restricted metabolomics using capillary electrophoresis-mass spectrometry||10/17/2018|
|A New-Method for the Determination of Acid Residues in Plant Matrices Using CESI-MS||03/14/2018|
|Innovations in Glycan Analysis on the PA 800 Plus, LC-MS and CESI-MS||03/10/2018|
|Intact Casein-A Model System for the Separation of Intact Phosphorylated Proteins by CESI-MS||01/25/2018|
|Improving the Detection Limits for Highly Basic Neuropeptides Using CESI-MS||01/10/2018|
|Ultra-sensitive Host Cell Protein Dection using CESI-MS with SWATH Acquisition||12/10/2017|
|Neutral OptiMS Cartridge Instruction Guide||08/31/2017|
|Expanding phosphorylation and post translational site mapping in proteomics using CESI-MS||08/24/2017|
|Detecting Challenging Post Translational Modifications (PTMs) using CESI-MS||08/20/2017|
|Solutions for Biotherapeutic Characterization||08/01/2017|
|Von Einzelmethoden zur Multimethode für polare Pestizide: Ist CESI-MS die Lösung||05/24/2017|
|Are Pork Extracts Present in My Gummy Bears? Gelatin Speciation by LC-MS/MS-poster||04/26/2017|
|CESI 8000 Plus paired with the TripleTOF 6600 for the analysis of Protein Therapeutics||02/28/2017|
|Improving Identification and Quantification of Polar Herbicides by CESI-MS||01/03/2017|
|Structural Characterization of Antibody Drug Conjugates (ADCs) By a Combination of Intact, Middle-up and Bottom-up Approaches Using CESI-MS||12/20/2016|
|Quantitation of Nucleotides and Nucleosides without derivatization using CESI-MS||12/15/2016|
|Unified workflow for monoclonal antibody charge heterogeneity||12/12/2016|
|Improved CESI-MS Glycopeptide Analysis using a Dopant Enriched Nitrogen Gas||12/09/2016|
|CESI-MS comparison of tryptic diges an assessment of bio similarity||11/28/2016|
|Intact Proteoform Characterization using CESI-MS||11/18/2016|
|CESI 8000 Plus OptiMS Adapter Kits||11/10/2016|
|Analysis of Intact MUPs (Major Urinary Proteins) from Mice by CESI-MS||11/09/2016|
|CESI-MS for Multilevel Characterization of Protein Therapeutics||10/12/2016|
|Highly Efficient and Sensitive Anionic Metabolic Profiling by Mass Spectrometry||09/12/2016|
|Solutions to Advance your Metabolomics Research||08/17/2016|
|Analysis of Disease-Induced Protein Mods Using CESI-MS||08/12/2016|
|Separations Part Number Catalog||08/01/2016|
|Method for CESI-MS Separation for Waters MS||08/01/2016|
|Waters Adapter Installation Guide||08/01/2016|
|Bruker Installation Guide||08/01/2016|
|CESI 8000 Plus High Performance Separations - OptiMS Adapter kit||07/12/2016|
|CESI-MS Separation Method for Bruker MS||07/08/2016|
|Glycomics and Glycoproteomics by CESI-MS for Biomarker Discovery and Biopharmaceutical Characterization||06/15/2016|
|UHPLC-ESI-QTOF-MS/MS based Lipidomics by Data-independent Acquisition||05/11/2016|
|Studying Kinetics of Chromatin Assembly with SWATH MS||05/11/2016|
|The Lipidyzer- a new platform for quantitative Lipidomics||05/11/2016|
|CESI-MS a technique for the characterization and analysis of both intact and digested biopharmaceuticals||05/11/2016|
|CESI 8000 Plus for CESI-MS Ease of Use||05/01/2016|
|Innovation for Biotherapeutic Comparability with BioPharmaView Software Solution Guide||05/01/2016|
|Capillary Electrophoresis and CESI-MS for Characterization of BioSimilars: rhuEPO||04/13/2016|
|OptiMS Adapter Kit Data Sheet||04/10/2016|
|Antibody-Drug Conjugate Structural Characterization – Part 1: Analysis of Conjugation Site DAR||03/16/2016|
|OptiMS Thermo MS Adapter Installation Guide||03/01/2016|
|Multilevel Characterization of Biologics with a Single Method||02/17/2016|
|Multilevel Characterization of Biologics with a Single Method-Jpn||02/17/2016|
|High resolution approach to the detection of insulin degradation products||02/16/2016|
|A new approach to the analysis ofanionicmetabolites by CESI-MS with negative ion electrospray ionization||02/16/2016|
|Host cell protein detection using CESI-MS with SWATH||02/09/2016|
|Conditioning Method Neutral Cartridge CESI 8000 Plus||01/15/2016|
|Peptide Separations Method Neutral Cartridge CESI 8000 Plus||01/15/2016|
|Protein Separations Method Neutral Cartridge CESI 8000 Plus||01/15/2016|
|General Separations Methods Other Than Peptides and Proteins Neutral Cartridge CESI 8000 Plus||01/15/2016|
|Unification of Charge Heterogeneity, Purity, and Molecular Weight Analyses of mAbs into a Single Analysis||12/05/2015|
|Separations Product Overview||12/01/2015|
|Neutral OptiMS Capillary Data Sheet||12/01/2015|
|CESI How to (short) for E-book||12/01/2015|
|Increasing Throughput with Multi-Segment-Injection-MSI-CESI-MS||10/01/2015|
|Analysis of Anionic Metabolites by CESI-MS||10/01/2015|
|Compact Quantitative Proteomics Workflow Combining SILAC Labeling, Chromatographic pre-fractionation and CESI-MS with Neutral Capillary Surface||10/01/2015|
|Ionization efficiency, Ion Suppression and Detection Sensitivity of CESI-MS||10/01/2015|
|New High Resolution approach to the Detection of Insulin Degradation products||10/01/2015|
|New Approach to the Analysis of Anionic Metabolites by CESI-MS with Negative ion Electrospray Ionization||10/01/2015|
|Metabolomics: New technology needed for depper understanding of Biological functions in sample-limited cases||10/01/2015|
|Chiral Analysis of Methamphetamine and it’s Metabolite, Amphetamine in Urine by CESI-MS||09/10/2015|
|ExionLC AC Series Extended Specifications||09/01/2015|
|Sensitive Glycoform Profiling of b-Interferon-1a (Avonex) and recombinant human Erythropoietin by CESI-TOF-MS||09/01/2015|
|Separation and Analysis of Intact Prostate Specific Antigen (PSA) and its Proteoforms by CESI-MS Under Native and Denaturing Conditions.||09/01/2015|
|A covalent, cationic polymer coating method for the CESI-MS analysis of intact proteins and polypeptides||08/31/2015|
|Comprehensive Analysis of Recombinant Human Erythropoietin Glycoforms by Capillary Electrophoresis and Nanoflow Liquid Chromatography Coupled with Intact/Middle-Down Mass Spectrometry||08/30/2015|
|Characterization of Phospho- and Glycopeptides by CESI-MS: A Powerful Technique for Increasing Sensitivity||07/01/2015|
|Ultra-sensitive Host Cell Protein Detection using CESI-MS with SWATH Acquisition||06/01/2015|
|Breakthrough Applications to Expand and Speed Biopharmaceutical Characterization||06/01/2015|
|Characterization of Intact Prostate Specific Antigen (PSA) and Its proteoforms by CESI-MS under Native and Denaturing Conditions||06/01/2015|
|Comprehensive characterization of three IgG forms using CESI-MS||06/01/2015|
|In-line Separation by Capillary Electrophoresis Prior to top-down Mass Spectrometric Analysis enables Sensitive Characterization of Proteoforms||06/01/2015|
|The Application of Capillary Electrospray Ionization with Negative Ion Electrospray Ionization for the Analysis of Plant Metabolites||06/01/2015|
|The Effect of Ultra-low Flow on the Ionization of Biotherapeutics||06/01/2015|
|The Use of Capillary Electrophoresis Coupled to Mass Spectrometry (CESI-MS) for Quantitation of Nucleotides and Nucleosides||06/01/2015|
|Coffee at the Conference #1: Meeting Rawi Ramautar||06/01/2015|
|P213W Ultralow ESI-MS Flow Rates Make a Difference in The Analysis of Biotherapeutics||01/28/2015|
|P223W Evaluating the Addition of Supercharging Reagents During CESIMS for Identification and Characterization of Biopharmaceuticals||01/28/2015|
|Application of CESI-MS on SILAC-based Quantitative Proteomics||09/30/2014|
|Complete Primary Structure and Biosimilarity Assessment of Monoclonal Antibodies in a Single Analysis from a Single Enzyme Using CESI-Tandem Mass Spectrometry||09/30/2014|
|Introduction to CESI-MS Meeting||09/30/2014|
|Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI–MS-MS||09/30/2014|
|Qualitative and Quantitative Analysis of Post-translational Modifications Using CESI-MS||06/23/2014|
|Comprehensive Analysis of Recombinant Human Erythropoietin Glycoforms by Capillary Electrophoresis and Nanoflow Liquid Chromatography Coupled with Middle-down Mass Spectrometry||06/18/2014|
|Monoclonal antibodies primary structure and biosimilarityassessment in a single analysis using transient isotachophoresissheathlesscapillary electrophoresis-tandem mass spectrometry||06/15/2014|
|Evaluating the Addition of Supercharging Reagents During CESI-MS for Identification and Characterization of Biopharmaceuticals||06/01/2014|
|Comprehensive Characterization of Trastuzumab using a Single-Shot Peptide Mapping Approach with CESI-MS||04/14/2014|
|CESI-MS Analysis of Biofluids of Basic Drugs and Metabolites||04/14/2014|
|Rapid Characterization of Biologics with CESI-QExactive||04/07/2014|
|Efficient and Sensitive Characterization of Intact Proteins of Pharmaceutical Interest by CESI-MS||09/01/2011|
|An Introduction to CESI-MS||06/05/2011|
|CESI-MS of Intact Proteins||06/01/2011|
|Analysis of Fentanyl and It's Metabolite, Norfentanyl by CESI-MS (11-08008-P)||04/07/2008|
|Unleashing the Power of Your Mass Spectrometer Using Ultra Low Flow CESI||06/01/2005|
|Using CESI to Improve LOD & LOQ of Pharmaceuticals and Their Metabloites||06/01/2005|
|New Horizons for Metabolic Profiling of Urine|
|High Resolution Intact Glycoprotein Analysis by CESI-MS (11-0809-P)|
|Sheathless Capillary Electrophoresis - Mass Spectrometry (P-14618)|
|Analyzing Intact Proteins and Protein Complexes with CESI-MS|
|CE-ESI-MS MS as a tool in Protein Glycosylation Analysis|
|CE - Separation of Multiphosphorylated H1b|
|Generate High Resolution Separations of Intact Peptides for Online MS Analysis (CESI)|
|Generate High Resolution Separations of Intact Peptides for Online MS Analysis|
|Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI-MS-MS|
|Multilevel Characterization of Biotherapeutics using CESI-MS: from Intact Protein to Peptide Mapping Approach|
|Polar Pesticide Analysis by CESI-MS|
|Probing a new volume regime in metabolomics by CESI|
|Therapeutic antibodies and related products design manufacturing and controls|
|Introducing the CESI 8000 High Performance Separation-ESI Module|
|Overcoming the Challenges of Quantifying Highly Polar Amines|
|NGB webinar-new protein modality|
CESI-MS allows for a more robust system with ultra-low-flow < 10 nL/min, into the mass spectrometer resulting an overall increase in ionization efficiency.
Samples are often limited in quantity. CESI-MS has nL sample consumption, leaving most of the material available for analysis by orthogonal techniques.
Use the same method and reagents for multi-level characterization of protein therapeutics. Switch between pos and neg ion modes without changing setup.
|Dimensions||29.2 in (74.2 cm) H x 25 in (63.5 cm) W x 28.4 in (72.1 cm) D|
|Portable Lab Bench||36 in x 30 in (91.4 cm x 76.2 cm)
Height adjusts 27 in to 44 in (69 - 112 cm)
|Weight (uncrated)||188 lbs (85.3 kg)|
|Electrical Requirements||Voltage: 100 - 240 V; 50/60 Hz|
|Sample Trays||2 x 48 CESI vials / 0.3 mL microvials|
|Buffer Tray||2 x36 CESI vials|
|Pressure Delivery Range||-5 to +100 PSI|
|Required Sample Volume||5 μl when using NanoVias|
Single continuous separation capillary is contained within the OptiMS cartridge
In stand-alone CE mode, UV/VIS, PDA, or LIF detection can be selected
Sample analysis from as little as 5 μL
The integration of Capillary Electrophoresis with Electrospray Ionization into a single dynamic process within the same device brings new capabilities to researchers.
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