Fully understand drug candidate glycoprofiles with pipeline-specific solutions.
Gather critical high-resolution information and site-specific data points with advanced glycan analysis for complex biologic development.
Fully understand drug candidate glycoprofiles with pipeline-specific solutions.
Gather critical high-resolution information and site-specific data points with advanced glycan analysis for complex biologic development.
Explore the latest and trending topics
Webinar
Dig deeper and identify new PQAs
Learn about the link between glycation and color change in final drug products along with how to develop assays for rapid monitoring and tracking of these PTMs.
Webinar
Enable fast turn around for process development
A high-throughput multi-capillary electrophoresis glycan analysis method to monitor glycan profiles of and support screening large numbers of samples.
Glycan analysis provides important information on critical quality attributes (CQAs) that could affect stability, safety and efficacy of a protein therapeutic.
Specific needs in understanding the glycosylation profiles change throughout the drug development process, but the requirement for high-resolution glycan information remains the same and is essential to help ensure product quality.
Address pipeline-specific challenges with glycan analysis workflows based on capillary electrophoresis (CE) and mass spectrometry (MS) to support rapid screening, in-depth characterization and lot-to-lot comparisons.
Workflow
Find a simpler path to market with scalable N-linked glycan analysis solutions that rapidly identify therapeutic antibody glycosylation profiles.
Thousands of samples, including those containing N-linked glycans, must be screened monthly in the early stages of development, driving the need for high-throughput assays to shorten development time.
Meet the need for large-scale sample analysis and glycan profiling throughout development with robust, high-throughput, CE-based workflows that integrate sample preparation, multi-channel separation and screening assays with intuitive data analysis software for rapid reporting.
Resources
Technical note
Reproducible glycan analysis for clone selection
Enable separation of a 96-well plate in under 2 hours with an N-linked glycan analysis workflow.
Technical note
Eliminate labor-intensive bench work and provide a higher throughput in N-linked glycan analysis with highly consistent results
Streamline N-linked glycan analysis using automated sample preparation with a magnetic bead-mediated glycan workflow followed by capillary electrophoresis (CE).
Workflow
Tackle the complex analytical challenges of modern therapeutics.
Intact protein analysis, routinely performed at different stages of monoclonal antibody (mAb) development, is essential for confirming the identity of glycoforms and monitoring product quality. However, increasingly complex glycoform distributions make it challenging to obtain detailed information about glycosylation on complex therapeutic proteins.
LC-MS workflows and data analysis software optimized for biopharma, enable rapid profiling of intact proteins for in-depth characterization. Confident peak assignment and better understanding of the location of glycosylation provide the comprehensive data needed for making critical decisions
Resources
Technical note
Accurate peak assignment becomes less daunting with detailed information about glycosylation on complex therapeutic proteins
Enable accurate and comprehensive glycopeptide characterization for routine, in-depth analysis of next-generation protein therapeutics and standard monoclonal antibodies (mAbs).
Technical note
Facilitate in-depth characterization of therapeutic proteins
Differentiate positional isomers of O-glycopeptides and leverage electron activated dissociation (EAD) to elucidate complex glycosylation profiles in protein therapeutics.
Workflow
Keep pace, with batch comparison workflows designed for confidence in quality.
Routine characterization of biosimilars or batch comparison of manufactured biologic samples is critical for maintaining biotherapeutic quality throughout development and production.
Monitor glycosylation profiles the intact or subunit level with flexible LC-MS solutions providing in-depth characterization and reliable monitoring of known PTMs.
Webinar
Facilitate clone selection with high-throughput glycan profiling
Get insight into high-throughput strategies for glycan analysis to condense development timelines.
EAD fragmentation explained
See electron activated dissociation (EAD) fragmentation in action for large molecules, and understand the benefit of EAD for identifying and localizing glycosylation.
Technical note
Confident identification and characterization of advanced glycation end products
Learn how electron activated dissociation (EAD) enables near-complete fragmentation of advanced glycation end products (AGEs) while retaining the AGE moieties for confident sequence identification, accurate localization
Technical note
Reproducible glycan analysis for clone selection
Enable separation of a 96-well plate in under 2 hours with an N-linked glycan analysis workflow.
Technical note
Eliminate labor-intensive bench work and provide a higher throughput in N-linked glycan analysis
Streamline N-linked glycan analysis using automated sample preparation with a magnetic bead-mediated glycan workflow followed by capillary electrophoresis (CE).
Technical note
Accurate peak assignment becomes less daunting with detailed information about glycosylation
Enable accurate and comprehensive glycopeptide characterization for routine, in-depth analysis of next-generation protein therapeutics and standard mAbs.
Technical note
Facilitate in-depth characterization of therapeutic proteins
Differentiate positional isomers of O-glycopeptides and leverage electron activated dissociation (EAD) to elucidate complex glycosylation profiles in protein therapeutics.
Technical note
Advanced tools for identifying and monitoring CQAs
Reliable processing, visualization, reviewing and reporting tools offer an easy path for decision making in biopharmaceutical development.
Take control of the unknowns. Gain confident sequence confirmation and localization of post-translational modifications (PTMs) at the sub-unit level.
Confidently select lead candidates and ensure reproducible product quality. Discover fast and reliable solutions that simplify identification and characterization of complex molecules at the intact level.
Pursue the end goal with confidence. Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.