Glycan analysis

Fully understand drug candidate glycoprofiles with pipeline-specific solutions. 

Gather critical high-resolution information and site-specific data points with advanced glycan analysis for complex biologic development.

Overview

Glycan analysis provides important information on critical quality attributes (CQAs) that could affect stability, safety and efficacy of a protein therapeutic.

Specific needs in understanding the glycosylation profiles change throughout the drug development process, but the requirement for high-resolution glycan information remains the same and is essential to help ensure product quality.

Address pipeline-specific challenges with glycan analysis workflows based on capillary electrophoresis (CE) and mass spectrometry (MS) to support rapid screening, in-depth characterization and lot-to-lot comparisons.

Manage development timelines with rapid N-linked glycan analysis

Workflow

Find a simpler path to market with scalable N-linked glycan analysis solutions that rapidly identify therapeutic antibody glycosylation profiles.

Thousands of samples, including those containing N-linked glycans, must be screened monthly in the early stages of development, driving the need for high-throughput assays to shorten development time. 

Meet the need for large-scale sample analysis and glycan profiling throughout development with robust, high-throughput, CE-based workflows that integrate sample preparation, multi-channel separation and screening assays with intuitive data analysis software for rapid reporting.

  • Streamlined sample preparation
  • Rapid method development with parallel processing
  • High-throughput, parallel screening of released N-linked glycans
  • Reproducible migration times and accurate glycan peak assignments
  • Ready for integration into automation

Confirm glycoform identity with detailed glycosylation analysis

Workflow

Tackle the complex analytical challenges of modern therapeutics.

Intact protein analysis, routinely performed at different stages of monoclonal antibody (mAb) development, is essential for confirming the identity of glycoforms and monitoring product quality. However, increasingly complex glycoform distributions make it challenging to obtain detailed information about glycosylation on complex therapeutic proteins.

LC-MS workflows and data analysis software optimized for biopharma, enable rapid profiling of intact proteins for in-depth characterization. Confident peak assignment and better understanding of the location of glycosylation provide the comprehensive data needed for making critical decisions

  • Accurate localization of glycosylation
  • Confident differentiation of position isomers

Monitor product quality during manufacturing

Workflow

Keep pace, with batch comparison workflows designed for confidence in quality.

Routine characterization of biosimilars or batch comparison of manufactured biologic samples is critical for maintaining biotherapeutic quality throughout development and production.

Monitor glycosylation profiles the intact or subunit level with flexible LC-MS solutions providing in-depth characterization and reliable monitoring of known PTMs.

  • Simple and accurate monitoring and identification of intact glycoforms
  • Capture of all common detectable peptides, including low-level glycopeptides
  • Ability to analyze and process large data sets

All resources

Filter:

Associated applications

Subunit mass analysis and middle-down

Take control of the unknowns. Gain confident sequence confirmation and localization of post-translational modifications (PTMs) at the sub-unit level.

Learn more
Intact protein analysis

Confidently select lead candidates and ensure reproducible product quality. Discover fast and reliable solutions that simplify identification and characterization of complex molecules at the intact level.

Learn more
Charge heterogeneity analysis

Pursue the end goal with confidence. Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.

Learn more