Take chimeric antigen receptor (CAR) T-cell therapy and other cell therapy programs to the next level with tailored analytical solutions that provide actionable answers.
Evaluate lentiviral vectors and lipid nanoparticles for gene editing and understand proteome changes with a collaborative team of experts.
Explore the latest and trending topics
Technical note
Analysis of pegRNA
Experience the impact of overcoming secondary structure challenges presented by large-sized oligonucleotides for gene editing. Learn how a high-resolution solution enables accurate and easy purity analysis of complex, synthetic prime editing guide RNA (pegRNA).
Webinar
Adducts and N-oxides: Understanding lipid nanoparticles (LNPs) for better drug delivery
Imagine taking control of your product quality and overcoming persistent challenges. Reclaim your time with a full solution for the structural elucidation of complex lipids using EAD and automated data processing.
The promise of cell therapy is staggering, bringing the possibility of a better life and even cures for diseases that were previously lethal. This promise requires the highest quality intermediate products, such as viral vectors, LNPs and CRISPR gene editing tools used for cell re-programming, and the need to understand the wider effects on the proteome.
Pursue improvements in medicine with a reliable partner for your analytical needs.
Workflow
Lentiviral vectors are complex modalities with quality that is linked to multiple attributes. User-friendly workflows let you determine viral protein profiles, including titer, genome integrity and nucleic acid impurities, on a single platform. Limitations on identifying host cell proteins can be overcome by solutions that offer the highest data quality.
Move your viral vector-based cell therapies forward with confidence.
Suited for:
Purpose-built for the biopharmaceutical scientist for efficiency and quality, enabling multiple samples to be run in parallel.
Purity and integrity analysis of RNA therapeutics, vaccines and single stranded oligos.
Effective quantification and determination of protein purity and size.
Pre-assembled bare-fused silica 8-capillary cartridge for the BioPhase 8800 system - 8 x 30 cm. (P/N 5080121)
Suited for:
Characterize therapeutic molecules with confidence with the kit-based system.
Purity and integrity analysis of RNA therapeutics, vaccines and single stranded oligos.
Effective quantitation and determination of protein purity and size.
Featured resources
Technical note
High-precision lentivirus titer determination and protein profiling
Take control of the quality of your lentiviral vectors with high-performance solutions. Learn how to characterize proteins, determine protein profiles, and enhance your understanding of process changes with intuitive wor
Technical note
Size distribution analysis of residual host cell DNA fragments in lentivirus
Remove barriers to assessing residual nucleic acids and control process-related impurities with accurate and reliable data. Characterize sizes and quantities of residual host-cell DNA for informed decision making.
Suited for:
Enjoy the perfect balance of sensitivity and robustness with a feature-rich microflow LC solution built for small and large molecule quantitation and characterization.
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Workflow
Comprehensive proteome characterization of gene-edited cells, such as CAR-T, requires depth and coverage from minimal sample amounts, while facing time pressures.
Fully understand changes in your product’s proteome that are associated with its quality. Leverage data with extraordinary intrascan dynamic range, specificity and reproducibility. Be empowered by high MS/MS data quality for low-abundance species, from small sample volumes and short runtimes.
Solution
Suited for:
Enjoy the perfect balance of sensitivity and robustness with a feature-rich microflow LC solution built for small and large molecule quantitation and characterization.
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
All resources
Technical note
High-precision lentivirus titer determination and protein profiling
Take control of the quality of your lentiviral vectors with high-performance solutions. Learn how to characterize proteins, determine protein profiles, and enhance your understanding of process changes with intuitive workflows.
Technical note
Size distribution analysis of residual host cell DNA fragments in lentivirus
Remove barriers to assessing residual nucleic acids and control process-related impurities with accurate and reliable data. Characterize sizes and quantities of residual host-cell DNA for informed decision making.
Webinar
Adducts and N-oxides: Understanding lipid nanoparticles (LNPs) for better drug delivery
Imagine taking control of your product quality and overcoming persistent challenges. Reclaim your time with a full solution for the structural elucidation of complex lipids using EAD and automated data processing.
Set your own schedule for CRISPR/Cas9 gene editing with innovative, intuitive analytical solutions. Unleash the potential of your Cas9 messenger RNA (mRNA), single guide RNA (sgRNA) and Cas9 proteins by understanding quality, purity and safety and assessing on/off target effects.
Expand the possibilities of drug delivery with innovative analytical solutions for lipid raw materials, LNPs and other non-viral carriers. Move beyond boundaries in structural elucidation and monitoring of analytes to estabilish confidence in the quality and stablity of your products.
Optimize workflows to reliably detect and monitor process-related impurities. Ensure the safety of next-generation viral products with accurate, reproducible sizing of residual DNA and RNA and simultaneous quantitation.
Optimize your processes with solutions that overcome the analytical challenges of viral vector-based drugs. Take control of full and empty ratios and protein and genome profiles. Break down the boundaries of protein and post-translational modification (PTM) characterization with dedicated high-resolution workflows offering unprecedented depth.