Spotlight on: targeted protein degraders

Cyclic peptides are stable, bioactive molecules that resist enzymatic breakdown and can target protein–protein interactions, making them valuable for treating conditions such as autoimmune disease, transplant rejection, and inflammation. While these complex molecules are challenging to analyze, advanced LC MS platforms like the SCIEX 7500+ and 7600+ systems deliver the sensitivity and resolution needed to advance their therapeutic potential.

SCIEX OS software streamlines instrument control and automates data processing to simplify lab workflows and support fast, informed decisions. It serves both new and experienced users by maintaining compliance through audit trails and role-based access, while automating routine tasks so scientists can focus on discovery. Designed for all the latest SCIEX mass spectrometry systems and now enhanced with Windows 11 support to meet IT security policies and reduce cybersecurity risks.

GLP-1 is a multifaceted hormone that regulates blood glucose, influences appetite and weight, and provides cardiovascular benefits. Continued research and development of GLP-1-based therapies promise to advance and expand potential uses. The sensitivity, specificity, and versatility of LC-MS plays a major role in advancing GLP-1 research with new insights.

Bile acid biochemistry was once poorly understood, but growing interest in the gut-brain axis and microbiome has sparked new research. LC-MS technology is advancing knowledge of bile acids' roles and potential as therapeutic targets and biomarkers.

Fentanyl has garnered significant attention in recent years due to its critical role in both medical and illicit contexts. As a compound, it offers unparalleled pain relief, but also contributes to an alarming rate of opioid-related overdoses. Studying fentanyl is essential to developing effective therapeutic applications, understanding its pharmacokinetics, and addressing the public health crisis it poses. LC-MS/MS has emerged as a transformative technology in advancing fentanyl research, providing precise and comprehensive analytical capabilities.

Oligonucleotides are pivotal in genetic research, diagnostics, and therapeutics. Explore the intricacies of these molecules and how LC-MS technologies are propelling their research to new heights, enabling scientists to achieve exceptional levels of accuracy in oligonucleotide characterization and quantitation.

The third topic in the Spotlight on series explores lipid mediators, a highly potent family of signaling molecules, perhaps best known for their role in inflammation. Due to their potent biological activities and often transient existence, precise and sensitive analytical techniques are essential for their study.

Get a deeper understanding of what makes nitrosamines a concern, what is being done to understand and test for nitrosamines, and how SCIEX LC-MS solutions can help give you confidence in your quantitation needs: for today and tomorrow.

PFAS are an extensive, complex group of manufactured chemicals that are ubiquitous throughout the environment, accumulate from many different sources and whose consumption is currently unavoidable. With accumulating toxicity a rising concern, sensitive and resilient analysis is key to understanding exposure risks. LC-MS is considered the gold standard for detecting and quantifying PFAS molecules and has become the “defacto” methodology for analysis.

The second topic in the Spotlight on series covers targeted protein degraders (TPDs), a cutting-edge approach in the field of drug development. By leveraging an event-driven mechanism that degrades unwanted or harmful proteins, rather than the traditional occupancy-driven approach, TPDs offer several significant therapeutic benefits that make them particularly promising for treating challenging conditions.