Accelerate lipidomics discoveries from molecular insight to biological impact
Lipidomics
Lipids play a critical role in cellular function, signaling pathways, metabolism, and disease progression. As researchers uncover the lipids' growing influence in human health, lipidomics has become an essential tool for understanding complex biological systems and identifying new opportunities for biomarker discovery, therapeutic development, and precision medicine.
SCIEX helps lipidomics researchers generate deeper biological insights with the confidence, sensitivity, and scalability needed to accelerate discovery. From comprehensive lipid profiling to targeted quantitation, our solutions help scientists turn complex lipid data into meaningful biological understanding.
Advancing lipidomics research
Transform lipid complexity into actionable biological insights
The lipidome contains thousands of structurally diverse molecules that influence virtually every aspect of biology. Understanding these molecules and their interactions can reveal new disease mechanisms, therapeutic targets, and biomarkers for diagnosis and patient stratification.
SCIEX technologies combine advanced mass spectrometry, streamlined workflows, and powerful data analysis capabilities to help researchers navigate the complexity of lipid biology. The result is greater confidence in lipid identification, quantitation, and interpretation across a wide range of research applications.
Whether exploring metabolic disorders, cardiovascular disease, neurodegeneration, cancer, or inflammation, SCIEX helps researchers accelerate progress from biological questions to meaningful discoveries.
Comprehensive lipid profiling
Targeted identification and quantitation
SCIEX solutions for targeted lipidomics are built using proven technology that delivers highly accurate, selective, sensitive and reproducible quantitation.
The SCIEX Triple Quad 6500+ system and the SCIEX 7500 system target thousands of lipids in a single experiment, rapidly switching between positive-ion and negative-ion mode to quantify potential biomarkers and elucidate metabolism at the lipid level.
Equipped with electron activated dissociation (EAD) technology, the ZenoTOF 7600 system enables full characterization of lipid species, all within a single experiment, and supports:
- The speed, sensitivity and dynamic range required for large-scale quantitative lipid profiling
- The characterization and structural elucidation of lipid species using EAD
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Targeted profiling of lipid mediators
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Achieve broad lipid quantitation using a high-throughput targeted lipidomics method
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Characterization of liposomes as a drug delivery vehicle
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Cutting into tallow: A lipidomic exploration of animal-based and alternatively sourced meat
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Quantitative and qualitative analysis of steroids by high-resolution mass spectrometry
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Quantitative and qualitative analysis of lipid mediators using the ZenoTOF 8600 system
Discovery lipidomics
Uncover new biological signals and emerging biomarkers
Many of the most important biological discoveries begin with unanswered questions. Untargeted lipidomics enables researchers to explore lipid biology without predefined assumptions, revealing new pathways, biomarkers, and disease mechanisms. SCIEX discovery lipidomics solutions provide the sensitivity and analytical depth required to characterize complex lipid populations and generate comprehensive datasets that support new scientific insights.
Discover how SCIEX can help you:
- Expand lipidome coverage across complex samples
- Confidently identify and characterize unknown lipid species
- Generate high-quality datasets for systems biology research
- Compare lipid changes across biological conditions and populations
- Accelerate biomarker discovery and validation workflows
When biological complexity increases, SCIEX helps researchers move from observation to understanding with greater speed and certainty.
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Complete structural elucidation of lipids in a single experiment using electron activated dissociation (EAD)
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Qualitative flexibility combined with quantitative power
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Improved lipid identification using the ZenoTOF 8600 system for untargeted lipidomics analysis
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Unlock Structural Insights in Lipidomics
Discover how Electron Activated Dissociation (EAD) on the ZenoTOF 7600 system enables confident localization of double bonds in fatty acids—advancing structural characterization in lipidomics research.
Featured workflow
Improve selectivity with differential ion mobility
Accurate lipid quantitation requires distinguishing the target lipid species from isomers, interferences and background. The SelexION device adds an orthogonal strategy for separation of isobaric and isomeric species and supports:
- Gas phase separation of the lipid classes prior to the MS/MS analysis
- Easy installation by the user in minutes
- Coupling with flow injection analysis (FIA) or chromatographic workflows (HPLC, UHPLC)
- Optional chemical modifiers to further increase the separation power, enabling the targeting of even the most difficult-to-resolve lipid isomers
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Differential mobility separation for improving lipidomic analysis by mass spectrometry
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Differential ion mobility separation of glycosylceramides (cerebrosides)
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Differential ion mobility separation of iso-elemental lipid species
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Resolution of ether- and diacyl-linked phospholipids by differential ion mobility spectrometry (DMS)
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Resolution of sphingomyelins in complex lipid extracts by differential ion mobility spectrometry (DMS)
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Sensitive and accurate quantitation of retinoic acid isomers in biological samples
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Differential mobility spectrometry resolves chlorine- and acetate-adducts of phosphatidylcholine (PC)
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Separation of bile acid isomers with differential mobility spectrometry
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Quantification of lipids by flow injection analysis and differential mobility spectrometry
Technologies supporting lipidomics workflows - Built to help researchers uncover more from every sample
Lipidomics research requires analytical technologies capable of delivering sensitivity, specificity, and flexibility across diverse workflows. SCIEX mass spectrometry platforms and software solutions help researchers confidently characterize lipid species, quantify biological changes, and generate data that supports meaningful scientific conclusions.
ZenoTOF 8600 system
Expand lipid coverage and achieve enhanced sensitivity for comprehensive lipidomics research.
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SCIEX 7600+ system
Deliver greater specificity, speed, and quantitative confidence across complex lipidomics workflows.
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ZenoTOF 7600 system
Support discovery-driven research with advanced fragmentation capabilities and high-resolution analysis.
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SCIEX 7500+ system
Generate highly sensitive quantitative data for targeted lipidomics applications.
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SelexION device
Add an orthogonal dimension of separation to distinguish closely related lipid species and enhance quantitation across complex samples.
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QTRAP 6500+ system
Generate sensitive, reliable quantitative data across diverse lipidomics applications and answer complex biological questions with confidence.
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ExionLC AE system
Achieve the reproducibility and reliability needed to support quantitative lipidomics workflows from injection to injection and batch to batch.
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SCIEX OS software
Streamline data acquisition, processing, and interpretation with a unified software platform designed to accelerate confident decision-making.
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Service
Keep your instruments performing at their peak with multiple options for response time, repair coverage and maintenance.
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Researchers advancing the future of human health
Thought leaders
Researchers advancing the future of human health
Extraordinary science in lipidomics
See how leading scientists are using lipidomics to answer complex biological questions and uncover new opportunities for disease understanding, biomarker discovery, and translational medicine. Explore the research, technologies, and collaborations helping transform scientific insight into real-world impact.
Explore extraordinary science
Meet Dr. Martin Giera
Associate Professor, Head Metabolomics Group, Leiden University Medical Center (LUMC)
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Chat with your peers about how to get the most out of your proteomics, metabolomics and lipidomics studies.
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