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The Power of Precision
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Advance your research with front-end instruments designed to help you realize the full power of your mass spectrometer. SCIEX has the broadest portfolio of ESI-MS front-ends that can facilitate various flow rates, sample requirements and sensitivities. No one else offers the entire range of analytical flow, microflow, nanoflow LC-MS and even ultra-low flow CESI-MS.
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Differential mobility spectrometry (DMS) and ion mobility spectrometry are analytical techniques used to separate ions based on their gas phase mobility. Multiple types of ion mobility devices exist, such as drift tubes, traveling wave, and high-field asymmetric waveform devices. Learn how you can separate yourself with Differential Ion Mobility.
The latest ion sources from SCIEX enable enhanced sensitivity and robustness with greater desolvation range across all MS platforms, from Triple Quad to QTRAP and QTOF.
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vMethod applications are pre-configured and verified LC-MS/MS methods that reduce the need for method development – significantly cutting the time, effort and money to deploy a new assay. Every vMethod provides method conditions, recommended sample prep, LC and MS conditions, and details for applicable MS/MS library databases for key applications.
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High resolution and QTRAP libraries can dramatically enhance the quality of your analysis, giving you much improved confidence in your data. With a comprehensive library at your fingertips, you can easily create methods and process targeted and non-targeted screening data on your complex samples, faster and easier than ever before.
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Boost the performance of your mass spectrometer and improve sensitivity, productivity, and data precision. iChemistry Solutions are the world's only reagents and consumables that are custom designed with your success in mind.
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QTOF – Quadrupole Time of Flight
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From substantiating new discoveries through to end-to-end validated workflows for high-throughput biomarker testing in the clinic, thousands of scientists worldwide depend upon mass spec innovation from SCIEX to advance their work in the fields of clinical, research, omics and diagnostics.
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How do you protect your reputation and meet today’s global food safety standards? Whether you are a commercial lab or a food manufacturer, the quality of your food testing data is vital to your business. SCIEX solutions help you meet maximum residue limits (MRLs) with high-quality data that you can genuinely count upon. With a portfolio of applications, your lab can quickly and easily react to diverse market needs.
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How do you ensure the integrity of your results in an industry that is never constant? By accurately detecting even the smallest compound angles you can deliver evidence that stands. SCIEX forensic analysis solutions deliver fast, highly accurate data across a multitude of compounds and biomarkers, from the known to the new and novel.
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Transform the capacity and capability of your biologics pipeline with complete end-to-end solutions that make your lab more productive, and more successful. With a longstanding track record in pharma discovery, development and manufacturing, our unparalleled application knowledge with best-in-class hardware, software and support all integrate to revolutionize your lab.
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The SCIEX Now Learning Hub offers the most diverse and flexible learning options available, with best-inclass content that helps you to get the most out of your instrument and take your lab to the next level. Available personalized learning paths based on the latest memory science ensure better knowledge retention, and automated onboarding and enrollment means you’ll get up and running faster.
SCIEX Now Learning Hub offers the most diverse and flexible learning options available, with best-in-class content that helps you to get the most out of your instrument and take your lab to the next level. Available personalized learning paths based on the latest memory science ensure better knowledge retention, and automated onboarding and enrollment means you’ll get up and running faster.
SCIEX Learning Manager provides you with the infrastructure to assign, monitor and report on your staff's competency through a single digital platform. Effectively manage the training process for new hires, ensure continuous staff development and access information with a single log-in to your SCIEX account.
You can browse, filter, or search our extensive list of training offerings. Choose from over 100 self-paced eLearnings or search for an instructor-led course near you. Once you select the course you want to take, you will be directed to Learning Hub for enrollment (login required).
SCIEX Now Online is the Everything, Anytime destination for all your SCIEX support needs. You can keep track of activities that matter most to you and manage your lab in the most efficient way possible. Extensive self-help resources like our deep Knowledge Base, enable you to solve many problems on your own. SCIEX Now is available 24/7 and your new SCIEX instruments are automatically added to your profile when you purchase.
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No one understands your needs and can support your systems better than we can. Our mission is to help you be successful, whether it's to repair your instrument, assist with your workflows, or help you maximize productivity in your lab. Whatever your challenge, global SCIEX Service and Support personnel are subject matter experts who are focused on mass spec and capillary electrophoresis, so you'll be able to achieve your scientific goals quickly and efficiently.
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SCIEX Now Learning Hub is much more than online courses. For the most comprehensive option, you can select Success Programs: personalized, blended online and in-person courses. If your needs are met by a visit from one of our training experts, you can choose multiple Onsite Training days to get your lab running. Visit a SCIEX training center in North America, Europe or Asia for intensive classroom and laboratory training. And your online courses are available any time, from anywhere, right here.
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If you have CE, LC or mass spec questions, then SCIEX has the answers. SCIEX support is the single destination for your system questions. We aim to fully assist you with virtually every application of our instruments, helping you to get the most out of your lab resources and assets.
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As a life science researcher, you need the tools and support to help you create the scientific foundation in pursuit of expanding the knowledge-base, whether it is understanding fundamental biology, finding new biomarkers, discovering ways to improve our quality of life, or other areas of research. We are committed to the same goals and put the very same dedication into our work to help you address your most significant research challenges.
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Intact biotherapeutic analysis is used throughout the product development life cycle to ensure both the proper selection of lead candidates and reproducible product quality. However, intact protein characterization of diverse and complex biotherapeutics can be extremely challenging, and it can present several analytical performance issues.
SCIEX offers a range of technology solutions specifically designed to address the analytical challenges of intact protein analysis, from candidate selection to post-commercialization. Our innovative LC-MS, CESI-MS and capillary electrophoresis (CE) technologies consistently deliver fast, accurate and reproducible assays and easy-to-interpret analysis for diverse and complex biotherapeutics.
Your increasing workload means you need highly reproducible intact protein data at your fingertips. SCIEX offers multiple approaches that enable you to routinely analyze even the most complex biotherapeutics throughout the development life cycle. Our powerful LC-MS, CESI-MS and CE technologies provide you with high-quality, highly reproducible intact protein characterization data, faster and more efficiently than previously possible.
Intact mass and subunit analysis by LC-MS provides confirmation of therapeutic mass and high-level heterogeneity. You can accelerate your routine intact and subunit biologic protein workflows with the ultra-compact and user-friendly X500B QTOF system, designed specifically for biologics and with LC-MS novices in mind. Its simple point-and-click interface makes data acquisition and processing within reach for every operator, regardless of their level of experience. High-quality data with good reproducibility means you can confidently determine the accurate mass of your protein isoforms, faster and easier than before.
CESI-MS provides orthogonal separation, delivering a more thorough characterization of complex intact biologic products when compared to traditional LC approaches. CESI-MS solutions from SCIEX reduce the complexity of analysis compared to standalone LC, which requires fractionation and MS detection.
Capillary electrophoresis (CE) intact protein assays provide information on purity, identity and charge heterogeneity of your intact biotherapeutics. SCIEX offers a tried-and-tested CE platform with proven assay portability for routine intact protein analysis. Advanced temperature-controlled capillary technology results in robust and reproducible analyses. The software interface is simple, visual and intuitive, and it requires no expertise for routine operation.
"Characterization of biomolecules by CE is a robust technology when the method is well described and controlled. This exercise supports and endorses the increased application of CE methodology within both development and QC laboratories within biopharmaceutical companies.” – B. Nunnally et al. (A series of collaborations between various pharmaceutical companies and regulatory authorities concerning the analysis of biomolecules using capillary electrophoresis, Chromatographia 2006, 64, 359–368)
Intact protein analysis is required throughout the drug development pipeline, from clone selection to post-commercialization. Whether you need to confirm your protein mass, analyze protein charge variants or execute routine standardized assays in a compliant environment, SCIEX has a tailored solution to meet your needs.
For labs that need to perform routine mass confirmation and molecular heterogeneity analysis, the X500B QTOF system offers an easy-to-use platform that is accessible to mass spec users with varying levels of experience.
Discover the power of the Zeno trap with EAD fragmentation technology in this high-resolution accurate mass system.
Get high accuracy, reliability and repeatability across thousands of injections with maximum uptime.
Perform accurate mass analysis with the compact and streamlined X500B QTOF system and the renowned Turbo V™ ion source.
Intuitive point-and-click acquisition software makes it easier than ever to set up and run your methods.
Get up and running quickly with access to our online training programs focused specifically on biotherapeutic characterization.
Comprehensive workflow of intact and subunit mass analysis for monoclonal antibodies (mAb)
Solutions for biotherapeutic intact mass analysis
Intact analysis of antibody drug conjugates
Intact biotherapeutic mass analysis
Routine workflow for comparability assessment of protein biopharmaceuticals
Intact antibody drug conjugate (ADC) analysis
BioPharmaView software 2.0
X500B QTOF system overview
BioPharmaView software overview
Enabling the use of mass spectrometry throughout biopharmaceutical development
Biotherapeutic subunit mass analysis
Comparative multi-supplier lot analysis of trastuzumab using subunit analysis on the X500B QTOF system
Innovation for biotherapeutic comparability with BioPharmaView software
For labs that need to gain accurate mass information on biotherapeutics, CESI-MS offers a highly sensitive workflow that streamlines orthogonal charge variant analyses. This is particularly important for samples with limited volumes, or if you are working with toxic molecules such as antibody drug conjugates.
Achieve enhanced protein isoform separation and improve protein ionization with integrated capillary electrophoresis and electrospray ionization coupled with mass spectrometry (CESI-MS). The CESI 8000 Plus system can also function as a standalone CE analyzer.
Confidently identify low-abundance protein isoforms using this high-sensitivity accurate mass system with a wide linear dynamic range of detection.
Reach decisions on the most important critical quality attributes for biopharmaceuticals faster and more confidently.
Intact proteoform characterization using CESI-MS
A new approach to the analysis of intact MUPs (major urinary proteins) from mice by CESI-MS
CESI-MS for multilevel characterization of protein therapeutics
Structural characterization of antibody drug conjugates (ADCs) by a combination of intact, middle-up and bottom-up approaches using CESI-MS
For labs that need to perform regulated, intact biotherapeutic characterization in analytical development or in a compliant QA/QC environment, CE solutions from SCIEX offer the most complete end-to-end offering. Our solutions include comprehensive sample preparation chemistry kits, innovative hardware, powerful processing software and world-class support.
All reagents, capillaries and protocols necessary to perform intact biotherapeutic analysis are available in these validated chemistry kits.
Achieve maximal reproducibility in biotherapeutic assays with this industry and regulatory proven technology with temperature-controlled capillary technology.
The intuitive and visual software of the PA 800 Plus system, combined with expert worldwide support from SCIEX, makes setup fast and straightforward.
Intercompany study to evaluate the robustness of capillary isoelectric focusing technology for the analysis of mAbs
Evaluation of capillary zone electrophoresis for charge heterogeneity testing of monoclonal antibodies.
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