Metabolite Identification: Comprehensive Detection, Total Confidence

Advance Your Drug Metabolism Analysis: Comprehensive drug metabolism studies are vital in protecting both patient safety and the reputation of the pharma organization. Researchers in drug development have the enormous responsibility of safeguarding new drug candidates by analyzing pre-clinical and clinical samples to detect harmful metabolites.

Oversights can be detrimental, and you need absolute confidence that you can meticulously identify every metabolite in a sample, as quickly and efficiently as possible. SCIEX offers innovative comprehensive drug metabolism solutions, specifically with this need in mind.

We bring together the best-in-class LS-MS technology with powerful data processing software to transform your drug metabolism workflows. With our hardware, you will experience extraordinary sample coverage, sensitivity, linear dynamic range and acquisition speed. You will see low level metabolites and follow the high-level parent compound accurately in the same experiment.

That’s not all. Our powerful software takes you from data to answers in minutes, removing the need for manual cumbersome data processing and analysis. With advanced processing logic, you benefit from lightning speed interpretation, visualization, and reporting of your comprehensive metabolism and catabolism data.

Whether you work in small molecule drugs or more complex large molecule biotherapeutics, the comprehensive drug metabolism solutions from SCIEX will empower you to do more, see more and achieve more.

Solving the Challenges

Our innovative LC-MS solutions tackle the challenges of comprehensive metabolism head-on, so you can complete your studies as quickly as possible, and keep the drug development process moving. Never again will you miss low level or toxic metabolites, need to perform multiple injections to get complete sample data coverage, or be faced with cumbersome complex data processing.

  • You need to detect low-level metabolites that can potentially be harmful to patients. We give you exceptional sensitivity and 5-orders of linear dynamic range with the TripleTOF® 6600
  • You need to remove tasks that require unnecessary sample and instrument time. We give every detectable metabolite in a single injection with variable window SWATH® Acquisition
  • You need to process complex data to get the answers you need. We give you advanced data processing, interpretation and reporting all in one place with MetabolitePilot™ Software 2.0

Don’t Risk Missing Low-level Metabolites

You can’t afford to miss low abundance metabolites in your sample. That’s why the TripleTOF 6600 LC-MS System is the best choice for comprehensive metabolite and catabolite detection. The TripleTOF 6600 System not only gives you the extremely high sensitivity to see those low-level metabolites, but its >5 orders of dynamic range means you can accurately follow the high level parent compound in the same experiment. Without both sensitivity and dynamic range, you risk missing metabolites - something you can't afford to do.

Get Comprehensive Coverage and a Digital Archive in a Single Injection

Variable window SWATH Acquisition captures high-resolution MS/MS for all detectable peaks in a sample, so you can see low level metabolites which could be missed by an IDA method. Moreover, the MS/MS data from SWATH Acquisition is very high quality, allowing you to make confident structural assignments of your metabolites and catabolites, even in the presence of high-intensity sample components at the same retention time.

Take the Complexity out of Data Processing and Interpretation

All-in-one MetabolitePilot Software 2.0 makes metabolite identification fast and efficient with batch data import and automated method generation for up to 200 samples at a time. MetabolitePilot Software interprets and correlates metabolite structures and profiles, so you always see your data in context.

Webinar - Metabolite ID Using Variable Window SWATH Acquisition

Drug Metabolism: Do More, See More, Achieve More

Advanced Biotransform Solution

If you are responsible for performing comprehensive drug metabolism studies, you need a solution that gives you absolute confidence that you can see all the metabolites and catabolites in a drug candidate sample.

ExionLC™ AD

Delivers high-accuracy, reliability, and repeatability across thousands of injections with maximum uptime

TripleTOF® 6600

High-resolution accurate mass spec system ensures the highest confidence for drug metabolism and catabolism studies with high sensitivity and wide linear dynamic range of >5 orders

Variable window SWATH® Acquisition

Proprietary variable window SWATH Acquisition provides high-speed, high-resolution MS/MS data of all detectable metabolites in a sample with a single injection

MetabolitePilot™ Software

Small molecule and large molecule metabolite profiling and structure determination with enhanced visualization tools for accelerating your time to answers

Solutions Guide

Advanced Biotransform

Technical Note

MetID Using SWATH Acquisition

Bulletin

MP Software Bulletin

Technical Note

Therapeutic Peptide Catabolite ID

Technical Note

MetID of Payload Species for ADCs

Webinar

MetaboliteID Using SWATH with Variable Window Acquisition

Webinar

Metabolism for All Your Therapeutic Molecules

Solutions Guide

Biotransform Solutions Overview guide

SWATH Based Biotransformation

SWATH Based Biotransformation

 

Learning Center  
Novel LC-MS Tools for Advancing Drug Metabolism Studies (54:09 min) Watch
MetID Workflow Infographic Download
Comprehensive Metabolite Identification - A one-stop solution Download
Rapid Metabolite ID using MetabolitePilot Software and TripleTOF Systems Download