Advance your drug discoveries with reliable metabolite data that save time and money. Our range of solutions supports routine monitoring and complex identification.
Metabolite identification
Explore the latest and trending topics
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Brochure
Ease the burden of managing metabolite identification
As a leader responsible for metabolite identification in your organization, what keeps you awake at night and how can SCIEX help?
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Video
Improving end-to-end metabolite identification with LC-MS/MS
Learn about the SCIEX end-to-end solution for metabolite identification, from method development to analysis. We explore the potential for electron activated dissociation (EAD) fragmentation to allow better-informed decision making.
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Technical note
Rapid soft spot analysis using a routine biotransformation solution
See an approach to rapidly identify top metabolites in a routine manner
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Blog
Is “right first time, every time” a pipedream?
If we lived in an ideal world, it would be possible to unambiguously identify metabolites using a single analytical experiment. This analytical technique would need to be efficient and easily generate the information needed from a routine assay that is also robust, enabling confident decision-making during drug discovery.
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Blog
LC-MS analysis of targeted protein degraders and their metabolites testing 123
Targeted protein degraders (TPD) are a relatively new therapeutic modality that opens the potential to target disease-causing proteins. These disease-causing proteins have been highly challenging for traditional small-molecule therapeutics to treat, making TPDs an exciting new therapeutic modality.
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Webinar
Refine metabolite identification from targeted protein degraders
The identification of drug metabolites is a critical step in drug development due to their impact on drug efficacy and safety. Here, we discuss metabolite identification using unique fragments from EAD and CID spectra.
Overview
Confidently complete your metabolite identification studies through your development process with dependable instruments run on intuitive, compliant-ready software.
Our LC-MS systems offer fit-for-purpose sensitive and robust performance.
Small molecule metabolites
Workflow
Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry (LC-MS) reducing the need for additional safety testing during drug discovery. Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
- More confident identification of the site of metabolism
- Fit-for-purpose systems
- Save time and money during drug discovery
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Figure 1: An example analyte that EAD enabled the confident identification of glucuronide conjugation by using diagnostic fragment ions.
Small molecule metabolites
Suited for:
- More established routine Met ID assays
- Robust sensitive analysis
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
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X500R QTOF system
A uniquely engineered and versatile QTOF build to handle the demands of any high throughput laboratory.
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Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
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Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Small molecule metabolites
Suited for:
- More challenging Met ID assays requiring additional analytical power
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
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Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
See how complementary MS/MS spectra provided by electron activated dissociation (EAD) fragmentation enabled the identification of phase 1 metabolites to support drug metabolism studies.
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Technical note
Confident characterization and identification of glucuronide metabolites using diagnostic fragments from electron activated dissociation (EAD)
Read about a streamlined method for the characterization and identification of conjugated structures during drug metabolism studies.
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Technical note
Characterization and identification of therapeutic peptide catabolites
Read about rapid characterization and identification of therapeutic peptide catabolites from rat liver s9 fractions using the ZenoTOF 7600 system
Oligonucleotide Met ID/biotransformation
Workflow
Complete metabolite assignments from biotransformation of siRNA, antisense and other oligonucleotides using reliable and trustworthy high-resolution mass spectrometry solutions that ensure fragmentation optimization. Identify oligonucleotide-derived metabolites with confidence, despite large isobaric overlaps and high structural similarities. Use custom software modifications that meet your specific analytical needs.
- Confidently identify and assign metabolites with high-resolution mass spectrometry data
- Distinguish structurally similar oligonucleotide metabolites with fragmentation optimization
- Meet your specific analysis needs using custom software modifications
Oligonucleotide Met ID/biotransformation
Suited for:
- Detection and identification of relevant oligonucleotide biotransformations
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Oligonucleotide Met ID/biotransformation
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
X500B QTOF system
A purpose-built QTOF system, designed specifically to accelerate everyday biologics characterization.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
All resources
Filter:
-
Technical note
Rapid soft spot analysis using a routine biotransformation solution
See an approach to rapidly identify top metabolites in a routine manner
-
Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
See how complementary MS/MS spectra provided by electron activated dissociation (EAD) fragmentation enabled the identification of phase 1 metabolites to support drug metabolism studies.
-
Technical note
Confident characterization and identification of glucuronide metabolites using diagnostic fragments from electron activated dissociation (EAD)
Read about a streamlined method for the characterization and identification of conjugated structures during drug metabolism studies.
-
Technical note
Characterization and identification of therapeutic peptide catabolites
Read about rapid characterization and identification of therapeutic peptide catabolites from rat liver s9 fractions using the ZenoTOF 7600 system
-
Technical note
Metabolite ID and relative quantification of oligonucleotides in plasma
Learn about a method developed for the identification, relative quantitation and structural confirmation of oligonucleotide metabolites in plasma, with sequence coverage at levels down to 1%.
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Technical note
Identification and relative quantification of oligonucleotide metabolites from extracted rat plasma
Read about the identification, relative quantitation and structural confirmation of nine oligonucleotide metabolites spiked in a rat plasma extract.
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Brochure
Ease the burden of managing metabolite identification
As a leader responsible for metabolite identification in your organization, what keeps you awake at night and how can SCIEX help?
Associated applications
ADME-Tox and DMPK
Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME-Tox and DMPK. Rapidly and comprehensively characterize drug candidates with robust and sensitive solutions for identification, monitoring and quantitation.
Learn more
Biomarker quantitation
Explore the potential of trusted LC-MS/MS solutions designed to simplify and accelerate biomarker quantitation. Bring drug candidates through the development pipeline more efficiently and confidently with accurate results obtained using innovative hardware and software, lab-tested methods and expert support.
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High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence faster than ever before. Get the information you need to make go/no-go decisions as quickly as possible in the drug discovery phase of your work.
Learn more
Targeted protein degraders and PROTACs
Easily advance your targeted protein degraders and proteolysis targeting chimeras (PROTACs) with reliable and sensitive analytical data. Give your team the confidence to develop synthetic therapeutics with the support of the SCIEX technical team.
Learn more