LC-MS solutions built to support metabolite identification and monitoring no matter the complexity.
Metabolite identification
Explore the latest and trending topics
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Brochure
Ease the burden of managing metabolite identification
As a leader responsible for metabolite identification in your organization, what keeps you awake at night and how can SCIEX help?
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Video
Improving end-to-end metabolite identification with LC-MS/MS
Learn about the SCIEX end-to-end solution for metabolite identification, from method development to analysis. We explore the potential for electron activated dissociation (EAD) fragmentation to allow better-informed decision making.
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Webinar
Refine metabolite identification from targeted protein degraders
The identification of drug metabolites is a critical step in drug development due to their impact on drug efficacy and safety. Here, we discuss metabolite identification using unique fragments from EAD and CID spectra.
Overview
Wherever your research takes you, SCIEX is there to support your routine assays and tackle complex analytes with you. Your work is unique, and so is the way we back it.
Small molecule metabolites
Workflow
Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry reducing the need for additional safety testing during drug discovery.
Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
- Don’t leave metabolite identification to chance. Get the confidence you need with trusted SCIEX analytical solutions.
- Get the perfect balance of sensitivity, speed and robustness with LC-MS solutions from SCIEX.
- Uncover critical metabolic pathways with precision, move forward with confidence, and save time and money.
- Backed by decades of expertise, our service team ensures you get the most out of your SCIEX solutions.
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Figure 1: An example analyte that EAD enabled the confident identification of glucuronide conjugation by using diagnostic fragment ions.
Small molecule metabolites
Suited for:
- More established routine Met ID assays
- Robust sensitive analysis
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
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X500R QTOF system
A uniquely engineered and versatile QTOF build to handle the demands of any high throughput laboratory.
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Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
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Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Small molecule metabolites
Suited for:
- More challenging Met ID assays requiring additional analytical power
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
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Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
See how complementary MS/MS spectra provided by electron activated dissociation (EAD) fragmentation enabled the identification of phase 1 metabolites to support drug metabolism studies.
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Technical note
Confident characterization and identification of glucuronide metabolites using diagnostic fragments from electron activated dissociation (EAD)
Read about a streamlined method for the characterization and identification of conjugated structures during drug metabolism studies.
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Technical note
Characterization and identification of therapeutic peptide catabolites
Read about rapid characterization and identification of therapeutic peptide catabolites from rat liver s9 fractions using the ZenoTOF 7600 system
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Technical note
Differentiating oxidative metabolite isomers of the molecular glue, mezigdomide, using electron-activated dissociation (EAD)
Here we discuss a software-assisted drug metabolite identification and characterization workflow. The approach enables scientists to achieve increased confidence in metabolite structure assignments by utilizing information-rich electron-activated dissociation (EAD) spectra.
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 8600 system
The newest accurate mass platform with sensitivity levels up to 10x greater than existing SCIEX technology. This translates not only into the lower limits of quantitation but also into new enabled approaches to making biologically relevant discoveries that can be proved by the data.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
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Technical note
Improved lipid identification using the ZenoTOF 8600 system for untargeted lipidomics analysis
In this technical note, data-dependent acquisition (DDA) experimental data acquired by the ZenoTOF 8600 system were processed using MSDIAL 5.5 software to detect and identify lipid molecular species in human plasma samples. These results were compared to similar experiments performed on the ZenoTOF 7600 system.
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Technical note
Breaking the limits: An ultra-sensitive complementary fragmentation for the confident identification and characterization of drug metabolites
This technical note demonstrates an ultra-sensitive method for confidently identifying and structurally elucidating drug metabolites, leveraging the enhanced MS1 and electron-activated dissociation (EAD) MS/MS sensitivity of the ZenoTOF 8600 system.
Oligonucleotide Met ID/biotransformation
Workflow
Complete metabolite assignments from biotransformation of siRNA, antisense and other oligonucleotides using reliable and trustworthy high-resolution mass spectrometry solutions that ensure fragmentation optimization. Identify oligonucleotide-derived metabolites with confidence, despite large isobaric overlaps and high structural similarities. Use custom software modifications that meet your specific analytical needs.
- Confidently identify and assign metabolites with high-resolution mass spectrometry data
- Distinguish structurally similar oligonucleotide metabolites with fragmentation optimization
- Meet your specific analysis needs using custom software modifications
Oligonucleotide Met ID/biotransformation
Suited for:
- Detection and identification of relevant oligonucleotide biotransformations
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Oligonucleotide Met ID/biotransformation
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
X500R QTOF system
A uniquely engineered and versatile QTOF build to handle the demands of any high throughput laboratory.
Learn more
Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
All resources
Filter:
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Technical note
Rapid soft spot analysis using a routine biotransformation solution
See an approach to rapidly identify top metabolites in a routine manner
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Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
See how complementary MS/MS spectra provided by electron activated dissociation (EAD) fragmentation enabled the identification of phase 1 metabolites to support drug metabolism studies.
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Technical note
Confident characterization and identification of glucuronide metabolites using diagnostic fragments from electron activated dissociation (EAD)
Read about a streamlined method for the characterization and identification of conjugated structures during drug metabolism studies.
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Technical note
Characterization and identification of therapeutic peptide catabolites
Read about rapid characterization and identification of therapeutic peptide catabolites from rat liver s9 fractions using the ZenoTOF 7600 system
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Technical note
Metabolite ID and relative quantification of oligonucleotides in plasma
Learn about a method developed for the identification, relative quantitation and structural confirmation of oligonucleotide metabolites in plasma, with sequence coverage at levels down to 1%.
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Technical note
Identification and relative quantification of oligonucleotide metabolites from extracted rat plasma
Read about the identification, relative quantitation and structural confirmation of nine oligonucleotide metabolites spiked in a rat plasma extract.
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Brochure
Ease the burden of managing metabolite identification
As a leader responsible for metabolite identification in your organization, what keeps you awake at night and how can SCIEX help?
-
Technical note
Differentiating oxidative metabolite isomers of the molecular glue, mezigdomide, using electron-activated dissociation (EAD)
Here we discuss a software-assisted drug metabolite identification and characterization workflow. The approach enables scientists to achieve increased confidence in metabolite structure assignments by utilizing information-rich electron-activated dissociation (EAD) spectra.
-
Technical note
Innovative drug metabolite identification and characterization using electron-activated dissociation
Here we discuss a software-assisted drug metabolite identification and characterization workflow. The approach enables scientists to achieve increased confidence in metabolite structure assignments by utilizing information-rich electron-activated dissociation (EAD) spectra.
Associated applications
ADME-Tox and DMPK
Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME-Tox and DMPK. Rapidly and comprehensively characterize drug candidates with robust and sensitive solutions for identification, monitoring and quantitation.
Learn more
Biomarker quantitation
Explore the potential of trusted LC-MS/MS solutions designed to simplify and accelerate biomarker quantitation. Bring drug candidates through the development pipeline more efficiently and confidently with accurate results obtained using innovative hardware and software, lab-tested methods and expert support.
Learn more
High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence faster than ever before. Get the information you need to make go/no-go decisions as quickly as possible in the drug discovery phase of your work.
Learn more
Targeted protein degraders and PROTACs
Easily advance your targeted protein degraders and proteolysis targeting chimeras (PROTACs) with reliable and sensitive analytical data. Give your team the confidence to develop synthetic therapeutics with the support of the SCIEX technical team.
Learn more