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A direct injection method for the analysis of 6PPD-quinone (6PPD-Q) in water was described in this technical note. Using the SCIEX QTRAP 4500 system, the method achieved a mid-ng/L LOQ with a runtime of 8.5 min. Absolute recoveries between 97% and 108% were shown in 20 and 200 ng/L spikes into 5 different water samples. A real-world road runoff water sample had a measured 6PPD-Q concentration of 120 ng/L, highlighting that the method utility.
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