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SCIEX Triple Quad™ 4500系统快速检测β-内酰胺类抗生素中N亚硝基二甲胺杂质
Triple Quad™ 4500在橡胶塞3种硫化剂检测中的应用
Discover what makes the SCIEX QTRAP® LC-MS/MS system more than just a triple quad system. Access technical notes that demonstrate the practical application of the QTRAP system in food testing.
P-Phenylenediamines (PPDs) and its related chemicals have been widely used in the production industry of tires, belts, hoses and cables, and they are considered to be a group of very effective chemical antioxidants, anti-bending cracking agents, and provide excellent ability to protect rubber and its products from thermal degradation and decomposition [1]. Due to the widespread use of rubber products, PPDs has existed in the natural environment for decades, and it is oxidized by ozone to produce PPD-quinone. It has been reported that the half-life of PPD-quinone in water is at least five times that of PPD, and it is strongly toxic to aquatic organisms, with as little as 95ng/L killing young salmon [2]. At present, the commonly used detection methods for p-phenylenediamine and its metabolites are GC-MS and HPLC, which have high detection limits and serious false positive interference. In this study, SCIEX Triple Quad™ system was used to establish four methods for the detection of p-phenylenediamine compounds and 6PPD-quinone, which has the advantages of simplicity, high sensitivity and good accuracy, and provides a valuable means for the public and government regulators to monitor and detect this emerging environmental pollutant.
Sensitive MDLs of 0.08-0.2 ng/L for of 14 PFAS compounds in EPA method 537 were achieved, all of which meet or exceed the requirements of the US EPA’s UCMR3 list in a ten-minute run.
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A fast and reliable method for the detection of 5-(4’-(azidomethyl)-[1,1’-biphenyl-2yl]-1H-tetrazole Impurity in Sartan drugs was developed and validated. The linearity of the compound was good (R>0.995), and LLOQ, recovery and RSD of the method all met the requirements of pharmacopoeia. This method could be used for the quantitation.
Genotoxic Impurities (GTIs) are compounds that directly or indirectly damage cell DNA and can cause gene mutation or in vivo mutagenesis, may be carcinogenic or prone to carcinogenesis. Alkyl methylsulfonate is one of the common genotoxic impurities. Clinical studies have found that DNA alkylation of methylsulfonate can induce mutagenic effects. Methyl methylsulfonate and ethyl methylsulfonate have been reported in this regard. A LC-MS/MS method for the determination of genotoxic impurity methyl methylsulfonate and ethyl methylsulfonate were established by SCIEX Triple QuadTM 4500.The method has good specificity and no interference. The sensitivity of the method is high and the lowest LLOQ are 2 ng/ml and 10 ng/ml, respectively.This method provides a reference for the detection of these genotoxic impurities.
SCIEX Triple Quad� 4500 system quickly identify the authenticity of Colloid drugs and ensure the quality of Colloid drugs
4500 系列仪器 系统用户指南
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