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/content/dam/SCIEX/pdf/tech-notes/all/Pesticide-Screening-4500_QTRAP-5090212-01.pdf
QTRAP 4500 system with the ExionLC AC system enabled the LC separation of 29 fentanyl, its analogues, and metabolites, allowing quantitation at low concentrations in complex matrices such as human whole blood (matrix at 0.1 ng/mL). Method leverages the Scheduled MRM algorithm in Analyst Software 1.7, showed ~4 orders dynamic range.
QTRAP 4500 system with the ExionLC AC system enabled the LC separation of 29 fentanyl, its analogues, and metabolites, allowing quantitation at low concentrations in complex matrices such as human whole blood (matrix at 0.1 ng/mL). Method leverages the Scheduled MRM algorithm in Analyst Software 1.7, showed ~4 orders dynamic range.
/content/dam/SCIEX/pdf/tech-notes/cn/sciex-triple-quad-4500-lc-ms-slash-ms-system-on-simultaneously-detection-of-trimethylamine-and-trimethylamine-oxide-in-human-serum.pdf
In this technical note, we describe a rapid and sensitive analysis of a comprehensive panel of forensic compounds in human urine using the ExionLCTM AC HPLC system and the QTRAP�/Triple Quad� 4500 LC-MS/MS system. This forensic panel contains 93 compounds, and a total of 212 MRM transitions including internal standards are monitored.
Angiotensin II is the major active component in renin-angiotensin-aldosterone system, which is a hormone regulating water-electrolyte metabolism and blood pressure. As a result, Angiotensin II is important in diagnosis and treatment of cardiovascular disease, nephrosis and endocrinopathy. Angiotensin II is trace in plasma, making it difficult to determine. Herein, we report a method based on SCIEX Triple Quad™ 4500 LC-MS/MS system, using isotopic label of angiotensin II as internal standard, which is an accurate and sensitive to determine the concentration of angiotensin II in human plasma.
Amino acids and their derivatives are common biomarkers for human physiological processes. In this work, we report a metabolome profiling technique for analyzing metabolites containing amines and phenolic hydroxyls or phenols based on SCIEX Triple QuadTM 4500 System .A chemical derivatization strategy based on dansylation reaction for increasing the retention capacity of amines in reversed-phase chromatography and improving the ionization efficiency in mass spectrometry in a complex sample. We developed a fast quantitative method to detect 90 amine-containing metabolites (including amino acids, their methylated and acetylated products, etc.) in 15 minutes. Our results demonstrated that 72 amine metabolites can be detected in mouse tissues, which were used for target metabonomics analysis to find out the potential markers. In addition, we detected 72 amine metabolites in plasma and 88 metabolites in urine with this method. As amines and phenols are important groups of metabolites, profiling these metabolites using the current technique should already be useful for biomarker discovery and biological studies.
Characterization and Identification of flavonoids in Traditional Chinese Medicine Artemisia rupestris L. by SCIEX QTRAP� 4500
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